Synthesis and Pharmacological Significance of Isoxazoline Derivatives: A Mini review
Academic Science JournalFive-membered heterocycles, like isoxazolines, are an important class of compounds of bioorganic and pharmacological importance. They have been treated as useful intermediates for the transformation of a large number of bioactive molecules.
mohammed alwan
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Syntheses of Isoxazoline-Based Amino Acids by Cycloaddition of Nitrile Oxides and Their Conversion into Highly Functionalized Bioactive Amino Acid Derivatives [PDF]
, 2012 The present account illustrates the syntheses of isoxazoline- based amino acids by the cycloaddition of 1,3-dipolar nitrile oxides to the C–C double bond of unsaturated amino acid derivatives, with focus on the regio- and stereoselectivities of the ...
Fülöp, Ferenc +2 more
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A Non-coded β2,2-Amino Acid with Isoxazoline Core Able to Stabilize Peptides Folding through an Unprecedented Hydrogen Bond [PDF]
, 2022 Dedicated to Prof. Cesare Gennari on the occasion of his 70th birthday New peptidomimetics containing a beta(2,)(2)-isoxazoline amino acid, i.e. 5-(aminomethyl)-3-phenyl-4,5-dihydroisoxazole-5-carboxylic acid (Isox-beta(2,)(2)AA), were prepared and ...
Anastasi F. +7 more
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Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs
Beilstein Journal of Organic Chemistry, 2019 The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β ...
Juanjuan Feng +3 more
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Synthesis of some isoxazoline, isoxazole and pyrazole carboxylic acids as the precursors of new 1,2-diacyl-1-alkylhydrazines [PDF]
, 2013 A number of isoxazoline, isoxazole and pyrazole carboxylic acids or their esters has been synthesized via the 1,3-dipolar cycloaddition of corresponding nitrile oxides or diazomethane to unsaturated dipolarophiles.
Antonevich, I. P., Katok, Ya. M.
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Synthesis and Characterization of Some Amides Containing Isoxazoline Ring
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 This work involves synthesis of amides containing isoxazoline unit starting with chalcone; 4-[3-(3‾-nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen ...
Kh. F. Ali, Dh. F Hussein, J. H. Tomma
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Synthesis of some flurophenyl 4-oxocyclopentane[d]isoxazolines and their dioxolane derivatives [PDF]
, 2013 A number of new fluorophenyl 4-oxocyclopentane[d]isoxazolines and their dioxolane derivatives has been synthesized. The obtained substances are of the interest as the perspective biologically active compounds as well as the intermediates in total ...
Antonevich, I. P., Nesterova, S. V.
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Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives [PDF]
, 2012 10.1186/1472-6769-12-5BMC Chemical ...
Anilkumar, N.C. +10 more
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Scientific Reports, 2021 An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically ...
Ting-Bi Hua +4 more
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Molecules, 2022 Host inflammatory responses are key to protection against injury; however, persistent inflammation is detrimental and contributes to morbidity and mortality. Herein, we demonstrated the anti-inflammatory role of Arteannuin-B (1) and its new spirocyclic-2-
Gifty Sawhney +9 more
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