in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin [PDF]
Journal of Tropical Life Science, 2021 Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to syn-thesized multi ...
Tsaniyah Nur Kholilah +2 more
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Green Chemistry Letters and Reviews, 2022 A convenient and efficient [3 + 2] cycloaddition reaction of alkenes and alkynes with the in situ generated nitrile oxides from aldoximes in the presence of NaCl, Oxone and Na2CO3 has been developed to afford a series of isoxazoles and isoxazolines at ...
Run-Kai Fang +3 more
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Veterinary Evidence, 2019 PICO questionIn dogs with generalised demodicosis, are isoxazolines as effective as a combined formulation of imidacloprid and moxidectin at reducing mite count and the severity of associated clinical signs?Clinical bottom lineFive single-blinded ...
Sarah Long
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Implications of flexible spacer rotational processes on the liquid crystal behavior of 4,5-dihydroisoxazole benzoate dimers [PDF]
, 2015 The synthesis of some novel non-symmetric liquid crystal dimers, {3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-(decyloxy)benzoates (5a–d) and 4-{3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-{[6-(octyloxy)naphthalen-2-yl]ethynyl ...
Bechtold, Ivan H. +7 more
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Comparative in vitro evaluation of contact activity of fluralaner, spinosad, phoxim, propoxur, permethrin and deltamethrin against the northern fowl mite, Ornithonyssus sylviarum. [PDF]
, 2017 BackgroundNorthern fowl mites (Ornithonyssus sylviarum) are obligate hematophagous ectoparasites of both feral birds and poultry, particularly chicken layers and breeders.
Flochlay-Sigognault, Annie +5 more
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Büchwald-Hartwig reaction applied to synthesis of new luminescent liquid crystal triarylamines derived from isoxazoles [PDF]
, 2015 © 2015 Taylor & Francis Group, LLC. The present work describes the synthesis and characterization of novel series of triarylamines isoxazoles (TAA) addressed to the organic photovoltaic materials. Diarylisoxazoles were synthesized by sequential [3+2] 1,
Fernandes, T. H. M. +3 more
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Fast MacMillan's Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds. [PDF]
ACS Omega, 2022 The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated.
Corbisiero D +10 more
europepmc +3 more sources
Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity
Molecules, 2022 The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance.
Kseniya N. Sedenkova +11 more
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ScienceOpen Research, 2014 The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of
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1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones [PDF]
, 2010 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions ...
Kissane, Marie +2 more
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