The continuing significance of chiral agrochemicals. [PDF]
Pest Manag SciIn the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Jeschke P.
europepmc +2 more sources
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition [PDF]
, 2016 International audienceGlycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into glucose thereby affecting the levels of glucose in ...
Azay-Milhau, Jacqueline +16 more
core +2 more sources
Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity
Molecules, 2022 The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance.
Kseniya N. Sedenkova +11 more
doaj +1 more source
Ruthenium-catalyzed asymmetric reduction of isoxazolium salts : access to optically active Δ4-isoxazolines [PDF]
, 2018 A tethered MsDPEN–ruthenium catalyst reduces a series of isoxazolium salts, affording optically active Δ4-isoxazolines in moderate to good yields and enantioenrichment. The redundancy of heating or high pressures allowed for chemoselective reduction with
Chew, Renta Jonathan, Wills, Martin
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Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives [PDF]
, 2012 10.1186/1472-6769-12-5BMC Chemical ...
Anilkumar, N.C. +10 more
core +3 more sources
A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime
Beilstein Journal of Organic Chemistry, 2013 Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant.
Raoni S. B. Gonçalves +4 more
doaj +1 more source
1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones [PDF]
, 2010 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions ...
Kissane, Marie +2 more
core +1 more source
Chemical and Pharmaceutical Bulletin, 1964 5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
S, NOGUCHI, M, IMANISHI, K, MORITA
openaire +3 more sources
A comparative laboratory trial evaluating the immediate efficacy of fluralaner, afoxolaner, sarolaner and imidacloprid + permethrin against adult Rhipicephalus sanguineus (sensu lato) ticks attached to dogs [PDF]
, 2012 Variational methods are used for targeting specific correlation effects by tailoring the configuration space. Independent sets of correlation orbitals, embedded in partitioned correlation functions (PCFs), are produced from multiconfiguration Hartree-
Froese Fischer, Charlotte +5 more
core +1 more source
Synthesis and antibacterial studies of some novel isoxazoline derivatives [PDF]
Journal of the Serbian Chemical Society, 2007 A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and
TEJASKUMAR SHAH, VIKAS DESAI
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