Results 51 to 60 of about 4,990 (166)

T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

eLife, 2022
JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a life-threatening brain disease in immunocompromised patients. Inherited and acquired T cell deficiencies are associated with PML.
Matthew D Lauver, Ge Jin, Katelyn N Ayers, Sarah N Carey, Charles S Specht, Catherine S Abendroth, Aron E Lukacher   +6 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Genetic variability of the VP1 gene of BK and JC polyomaviruses in HIV-infected patients [PDF]

Medicinski Podmladak, 2015
Human polyomaviruses, BK virus (BKV) and JC virus (JCV), are world widely distributed in human population. After primary infection, BKV and JCV establish latency in kidneys and upper part of urinary tract. In seropositive healthy individuals asymptomatic
Karalić Danijela, Lazarević Ivana
doaj   +1 more source

An Accurate Genetic Colocalisation Method for the HLA Locus

HLA, Volume 107, Issue 5, May 2026.
ABSTRACT Genetic colocalisation analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalisation is rarely undertaken at the HLA locus, due to its complex linkage disequilibrium (LD) and high polymorphism density.
Guillaume Butler‐Laporte, Tianyuan Lu, Sam Morris, Wenmin Zhang, Gavin Band, Fergus Hamilton, Amanda Chong, Kuang Lin, Ruth Nanjala, J. Brent Richards, Mei‐Hsuan Lee, Ling Yang, Pang Yao, Liming Li, Zhengming Chen, Yang Luo, Iona Y. Millwood, Robin G. Walters, Alexander J. Mentzer   +18 more
wiley   +1 more source

Identification of Novel Wraparound Transcripts in JC Polyomavirus

Journal of Medical Virology
ABSTRACT JC polyomavirus (JCPyV) is a ubiquitous pathogen that causes progressive multifocal leukoencephalopathy (PML). Although a recent study using next‐generation sequencing (NGS) provided detailed transcriptome atlases for polyomaviruses (PyVs) such as BK polyomavirus and simian virus 40, the transcriptome of JCPyV remains poorly ...
Shun Iida, Kenta Takahashi, Sohtaro Mine, Tadaki Suzuki, Harutaka Katano   +4 more
openaire   +2 more sources

A Retrograde Trafficking Inhibitor of Ricin and Shiga-Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses

mBio, 2013
Polyomaviruses are ubiquitous pathogens that cause severe disease in immunocompromised individuals. JC polyomavirus (JCPyV) is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), whereas BK ...
Christian D. S. Nelson, Dan W. Carney, Aaron Derdowski, Alex Lipovsky, Gretchen V. Gee, Bethany O’Hara, Paul Williard, Daniel DiMaio, Jason K. Sello, Walter J. Atwood   +9 more
doaj   +1 more source

Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Sara Passerini, Davide Mariotti, Sara Messina, Valentina Mazzotta, Giulia Matusali, Andrea Antinori, Valeria Pietropaolo, Fabrizio Maggi, Luigi Rosa   +8 more
wiley   +1 more source

Beyond Human Papillomavirus (HPV): Detection of EBV and Polyomaviruses in Cervical and Anal Samples

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Colorectal and cervical cancers represent an important public health problem worldwide, particularly in Brazil. Colorectal cancer is one of the most frequently diagnosed malignancies worldwide and the most common cancer in both men and woman in Brazil.
Ana Carolina Silva Guimarães, Luana L. S. Rodrigues, Letícia Bomfim Campos, Katrini G. Martinelli, Nathália Silva Carlos Oliveira, W. Martin Kast, Charlotte A. Gaydos, Carlos Silva de Jesus, José H. Pilotto, Mariza G. Morgado, Tarik Gheit, Vanessa Salete de Paula   +11 more
wiley   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Polyomavirus JC microRNA expression after infection in vitro

Virus Research, 2016
The in vitro expression of the Polyomavirus JC (JCPyV) microRNAs, JC-miRNA-3p and -5p, at early time points post-infection was investigated. The expression of the JCPyV microRNAs was monitored in hematopoietic progenitor KG-1 cells and in kidney fibroblast-like COS-7 cells transformed with SV40 after infection with a JCPyV CY archetype viral clone. The
Giovannelli, I, CLAUSI, VALERIA GINA, Nukuzuma, S, DELLA MALVA, NUNZIA, NOSI, DANIELE, GIANNECCHINI, SIMONE   +5 more
openaire   +3 more sources