Results 71 to 80 of about 5,167 (169)

Polyomavirus Infection in Two Young Parrots: Assessment of Viral Distribution in Organs and Affected Tissues

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Avian polyomavirus (APyV) is responsible for diseases in birds belonging to several avian orders, including Psittaciformes, Anseriformes, and other susceptible taxa. APyVs appear to be able to replicate in various organs of susceptible bird species.
Gaia Casalino, Davide Messina, Clara Tolini, Giancarlo Bozzo, Antonio Lavazza, Francesco D’Amico, Antonella Bove, Francesco Pellegrini, Francesco D’Onghia, Diana Romito, Vito Martella, Canio Buonavoglia, Antonio Camarda, Elena Circella, Lipi Buch   +14 more
wiley   +1 more source

LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT We describe the first immunohistochemical analysis performed on brain lesion biopsies from two young individuals with Fanconi anemia neuroinflammatory syndrome (FANS). We identified aberrant activation of the LINE‐1 retrotransposon as a novel mechanism of neuroinflammation in individuals with hematological disorders.
Allison L. Bartlett, Kristie N. Ramos, Jamen R. Bartlett, Kenneth S. Ramos, Nathan Luebbering, Kasiani C. Myers, Parinda A. Mehta, Stella M. Davies   +7 more
wiley   +1 more source

High prevalence of the simultaneous excretion of polyomaviruses JC and BK in the urine of HIV-infected patients without neurological symptoms in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2012
OBJECTIVE: To evaluate the prevalence of the urinary excretion of BKV and JCV in HIV-infected patients without neurological symptoms. METHODS: Urine samples from HIV-infected patients without neurological symptoms were tested for JC virus and BK virus by
Luiz Henrique da Silva Nali, Cristiane de Campos Centrone, Paulo Roberto Palma Urbano, Augusto César Penalva-de-Oliveira, Jose Ernesto Vidal, Erique Peixoto Miranda, Claudio Sérgio Pannuti, Maria Cristina Domingues da Silva Fink   +7 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Azusa Ohtani, Masashi Iemura, Ken Watanabe, Arihiro Kohara   +6 more
wiley   +1 more source

Therapeutic potential of flavonols in the treatment of JCPyV

Microbiology Spectrum
JC polyomavirus (JCPyV) is a double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease with a high rate of morbidity and mortality. There are limited treatment options for patients diagnosed with PML,
Evan MacLure, Kaitlin Garabian, Bethany A. O'Hara, Wenqing Yuan, Jacob Kaiserman, Avraham S. Lukacher, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source

Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain.

PLoS Pathogens, 2014
JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal.
Gretchen Meinke, Paul J Phelan, Radha Kalekar, Jong Shin, Jacques Archambault, Andrew Bohm, Peter A Bullock   +6 more
doaj   +1 more source

A Review on JC Virus Infection in Kidney Transplant Recipients

Clinical and Developmental Immunology, 2013
The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue.
Serena Delbue, Mariano Ferraresso, Luciana Ghio, Camilla Carloni, Silvia Carluccio, Mirco Belingheri, Alberto Edefonti, Pasquale Ferrante   +7 more
doaj   +1 more source

JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells

mBio, 2019
The endemic human JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in vivo are not understood because the major target cells for virus in the brain do not express ...
Jenna Morris-Love, Gretchen V. Gee, Bethany A. O’Hara, Benedetta Assetta, Abigail L. Atkinson, Aisling S. Dugan, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source