Results 71 to 80 of about 4,990 (166)

Current Perspectives on JC Polyomavirus Transmission and Associated Diseases: Implications for Prevention in Risk Populations

Viruses
JC polyomavirus (JCPyV) is a worldwide-distributed human virus. Primary infection with JCPyV is usually asymptomatic and followed by a lifelong persistent infection.
Joana M Oliveira, Cristina Luxo, Ana Ana M Matos   +2 more
doaj   +1 more source

Reduced incidence of relapse after checkpoint inhibitors relative to brentuximab vedotin as salvage therapy before allogeneic stem cell transplantation for refractory/relapsed Hodgkin lymphoma: A retrospective analysis

British Journal of Haematology, Volume 207, Issue 4, Page 1684-1689, October 2025.
Eighty‐two patients were eligible for allogeneic transplantation (Allo‐SCT) at our Institution between April 2014 and August 2022. Of these, 72 actually received Allo‐SCT, n = 44 after checkpoint inhibitor (CPI) containing salvage therapy (CPI cohort) and n = 28 with brentuximab‐vedotin (BV) containing therapy without CPI (BV cohort).
Jacopo Mariotti, Chiara Pinton, Laura Giordano, Daniela Taurino, Barbara Sarina, Chiara De Philippis, Daniele Mannina, Cristina Tentori, Armando Santoro, Stefania Bramanti   +9 more
wiley   +1 more source

High prevalence of the simultaneous excretion of polyomaviruses JC and BK in the urine of HIV-infected patients without neurological symptoms in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2012
OBJECTIVE: To evaluate the prevalence of the urinary excretion of BKV and JCV in HIV-infected patients without neurological symptoms. METHODS: Urine samples from HIV-infected patients without neurological symptoms were tested for JC virus and BK virus by
Luiz Henrique da Silva Nali, Cristiane de Campos Centrone, Paulo Roberto Palma Urbano, Augusto César Penalva-de-Oliveira, Jose Ernesto Vidal, Erique Peixoto Miranda, Claudio Sérgio Pannuti, Maria Cristina Domingues da Silva Fink   +7 more
doaj   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences

Small Structures, Volume 6, Issue 7, July 2025.
This illustration depicts a comprehensive strategy against monkeypox, showcasing its transmission, symptoms, and prevention. Centralized around nanomaterials and biosensors, it integrates early screening, Internet of Things, vaccination, and community involvement through collaboration among healthcare workers, scientists, researchers, social groups ...
Vishal Chaudhary, Lucky Lucky, Harsh Sable, Nikhil Bhalla   +3 more
wiley   +1 more source

Therapeutic potential of flavonols in the treatment of JCPyV

Microbiology Spectrum
JC polyomavirus (JCPyV) is a double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease with a high rate of morbidity and mortality. There are limited treatment options for patients diagnosed with PML,
Evan MacLure, Kaitlin Garabian, Bethany A. O'Hara, Wenqing Yuan, Jacob Kaiserman, Avraham S. Lukacher, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source

Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain.

PLoS Pathogens, 2014
JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal.
Gretchen Meinke, Paul J Phelan, Radha Kalekar, Jong Shin, Jacques Archambault, Andrew Bohm, Peter A Bullock   +6 more
doaj   +1 more source

JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells

mBio, 2019
The endemic human JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in vivo are not understood because the major target cells for virus in the brain do not express ...
Jenna Morris-Love, Gretchen V. Gee, Bethany A. O’Hara, Benedetta Assetta, Abigail L. Atkinson, Aisling S. Dugan, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source

Characterization of Cells Transformed by the Human Polyomavirus JC Virus

Journal of General Virology, 1986
One unique feature of the prototype JC virus (JCV) (Mad 1) genome is the occurrence of a second TATA sequence within the early promoter region. A naturally occurring oncogenic variant of JCV (Mad 4) lacks this second TATA box. Several cell lines transformed by Mad 1, Mad 4 and simian virus 40 were characterized, in part to investigate whether the ...
C W, Mandl, R J, Frisque
openaire   +2 more sources