Results 191 to 200 of about 2,027,813 (387)

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

open access: yesAdvanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin   +5 more
wiley   +1 more source

Owl monkey astrocytoma cells in culture spontaneously produce infectious JC virus which demonstrates altered biological properties [PDF]

open access: bronze, 1987
Eugene O. Major   +4 more
openalex   +1 more source

Association Between Liver Function Grade and Post‐Hepatectomy Liver Failure in Patients With Hepatocellular Carcinoma: A Latent Class Analysis

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
We retrospectively analyzed clinical data from patients who underwent hepatectomy for hepatocellular carcinoma (HCC) using LCA‐based grading system. These findings provide a new risk stratification framework for the design of precision surgery to treat patients with HCC.
Ling Liu   +5 more
wiley   +1 more source

Confronting JC virus and Homo sapiens biological signatures 

open access: yesFrontiers in Bioscience, 2013
The present report describes the peptide commonality between JC virus (JCV) and the human proteome at the heptamer level. In total, 53 viral heptapeptides occur in functionally important human proteins with potential consequences for host functions and JCV pathogenesis.
openaire   +4 more sources

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng   +10 more
wiley   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

open access: yesAnalysis &Sensing, EarlyView.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro   +7 more
wiley   +1 more source

Regulation of JC virus expression in B lymphocytes [PDF]

open access: bronze, 1994
Peter Rieckmann   +2 more
openalex   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

open access: yesAnimal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang   +11 more
wiley   +1 more source

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