Results 101 to 110 of about 167,128 (299)
Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
Drug Design, Development and Therapy, 2019 Zhongxiang Xiao,1,2 Fengli Xu,3 Xiaona Zhu,1 Bin Bai,1 Lu Guo,4 Guang Liang,1 Xiaoou Shan,3 Yali Zhang,2 Yunjie Zhao,2 Bing Zhang1,2 1Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, People’s Republic of China ...
Xiao Z +9 more
doaj
Asian Pacific Journal of Tropical BiomedicineObjective: To investigate the inhibitory effects of Ishige okamurae extract (IOE) against osteoclastogenesis in vitro and in vivo. Methods: The effects of IOE on osteoclast differentiation were examined in receptor activator of nuclear factor-KB ligand ...
Su-Hyeon Cho +5 more
doaj +1 more source
, 2011 (A) Sodium dodecyl sulphate-polyacrilamide gel electrophoresis of HSC cell lysates at days 2 and 7 of control cultures and cultures treated over 6 and 20 h with atorvastatin 10 mol/L, with and without U0126.
Isabella Aprigliano (45681) +3 more
core +1 more source
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
JNK Signaling Network and Cancer [PDF]
Genes & Cancer, 2013 Jun kinases (JNKs) form a major signaling hub involved in cell proliferation, differentiation, and apoptosis. JNKs belong to the family of mitogen activated protein kinase (MAPK) that is responsive to a variety of environmental stimuli.1-3 Typically, MAP kinase signaling modules progresses through the sequential phosphorylation of constituent MAP ...
openaire +2 more sources
, 2014 Podosomes are actin-based membrane protrusions that facilitate extracellular matrix degradation and motility of invasive cells. Podosomes can self-organize into large rosette-like structures in Src-transformed fibroblasts, osteoclasts and some highly ...
Hong-Chen Chen +3 more
core
Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
, 2014 A: Immunoblotting of total and phosphorylated JNK at day 7. B: Immunoblotting of total and phosphorylated JNK at day 12. C: The ratio of phosphorylated JNK to total JNK from data shown in A. D: The ratio of phosphorylated JNK to total JNK from data shown
Jielin Duan (520729) +12 more
core +1 more source
AgriFood: Journal of Agricultural Products for Food, EarlyView.ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley +1 more source
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Karslı, Gizem +23 more
core +2 more sources