Results 101 to 110 of about 177,354 (301)
Asian Pacific Journal of Tropical BiomedicineObjective: To investigate the inhibitory effects of Ishige okamurae extract (IOE) against osteoclastogenesis in vitro and in vivo. Methods: The effects of IOE on osteoclast differentiation were examined in receptor activator of nuclear factor-KB ligand ...
Su-Hyeon Cho +5 more
doaj +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
, 2014 Kymograph plots of JNK* activity (red = low, yellow/white = high) for (a) and (b) . Comparison between (a) and (b) reveals that JNK that is scaffolded and transported on the cytoskeleton (case (b)) can result in delivery of JNK and activation to JNK* at
Yen Ling Koon (545418) +2 more
core +1 more source
Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity
Advanced Science, EarlyView.An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou +10 more
wiley +1 more source
JNK Signaling Network and Cancer [PDF]
Genes & Cancer, 2013 Jun kinases (JNKs) form a major signaling hub involved in cell proliferation, differentiation, and apoptosis. JNKs belong to the family of mitogen activated protein kinase (MAPK) that is responsive to a variety of environmental stimuli.1-3 Typically, MAP kinase signaling modules progresses through the sequential phosphorylation of constituent MAP ...
openaire +2 more sources
, 2010 Kathleen Ponzetti1, Melissa King1, Anna Gates1, M Sawkat Anwer2, Cynthia RL Webster11Department of Clinical Science, Tufts Cummings School of Veterinary Medicine, Grafton MA, USA; 2Department of Biomedical Sciences, Tufts Cummings School of Veterinary ...
Kathleen Ponzetti +3 more
core
The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK
, 2003 The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) are activated by pleiotropic signals including environmental stresses, growth factors, and hormones.
Collins, Mary K. +3 more
core +1 more source
The role of JNK in the development of hepatocellular carcinoma [PDF]
, 2016 The cJun NH(2)-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that accounts for JNK-regulated tumor growth is unclear.
Garlick, David S. +3 more
core +1 more source
Advanced Science, EarlyView.In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei +18 more
wiley +1 more source