Results 81 to 90 of about 19,029,205 (280)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Exploring the Job Demands and Resources of Sandwich Generation Female Employees in Sri Lanka

Kelaniya Journal of Management
The significant challenges faced by the Sandwich Generation have garnered considerable attention over the past few decades. However, the unique job demands and resources experienced specially by female employees within this demographic are rarely ...
Danushka, K.W.U., Karunathilaka, K.G.G.S.   +1 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The mediating role of optimism and self-efficacy in the relationship between job autonomy and turnover intention [PDF]

Psihologija
This study sought to find empirical evidence that supports the Job Demands-Resources model’s extension, i.e., the inclusion of personal resources as a mediator between job resources and work-related outcomes in the model.
Mirković Biljana
doaj   +1 more source

Retirement effects of heavy job demands [PDF]

This study focuses on the influence of heavy job demands on retirement, using the available SHARE waves. Heavy job demands may have a direct and health mediated effect on individual retirement.
Golo Henseke
core  

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

The Evolving Demands and Resources of Live Entertainment: The Development of a Job Demands Resources Sport (JDRS) Model

Journal of Intercollegiate Sport
Utilizing the job demands resource (JDR) model, as a basis to learn and better understand the workplace experience of employees in live entertainment, we developed a model specific to sport.
Janelle Wells, Cheryl Gray, Elizabeth Taylor   +2 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Job Demands and Resources as Predictors of Burnout Dimensions in Special Education Teachers

European Journal of Investigation in Health, Psychology and Education
Background/Objectives. ICD–11 classifies burnout as a work-related issue arising from chronic workplace stress that has not been successfully managed. According to the Job Demands/Resources Model, job demands represent sources of stress and job resources
Vesna R. Jovanović, Čedo Miljević, Darko Hinić, Dragica Mitrović, Slađana Vranješ, Biljana Jakovljević, Sanja Stanisavljević, Ljiljana Jovčić, Katarina Pavlović Jugović, Neda Simić, Goran Mihajlović   +10 more
doaj   +1 more source