Results 71 to 80 of about 19,029,205 (280)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Work engagement and burnout of academics at South African higher education institutions: A job demands and resources perspective

SA Journal of Industrial Psychology
Orientation: The transformation of the academic landscape, exacerbated by COVID-19, creates an urgent need to understand escalating demands on academics and how resources could help overcome these challenges.
Mineshree Naidoo-Chetty, Marieta du Plessis, Jurgen Becker   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Representing teachers’ job characteristics and their subsequent outcomes by utilizing job demands-resources model (JD-R)

بهداشت و ایمنی کار, 2017
Introduction: Teaching has been reported stressful. Although, the majority of teachers aren’t anxious or unmotivated and they even consider their job valuable and satisfying.
Mojtaba Khosravi Danesh, Adel Mazloumi, Shaghayegh Zahraei, Abbas Rahimi Foroushani   +3 more
doaj  

Explaining employees' evaluations of organizational change with the job‐demands resources model [PDF]

Career Development International, 2009
PurposeDeparting from the Job Demands‐Resources (JD‐R) model, the paper examined the relationship between job demands and resources on the one hand, and employees' evaluations of organizational change on the other hand.Design/methodology/approachParticipants were 818 faculty members within six faculties of a Dutch university.
van Emmerik, I.H., Bakker, A.B., Euwema, M.   +2 more
openaire   +1 more source

Role resources and work-family enrichment: The role of work engagement [PDF]

, 2010
The majority of work-family research has focused on negative spillover between demands and outcomes and between the work and family domains (e.g., work-family conflict; see review by Eby, Casper, Lockwood, Bordeaux, & Brinley, 2005).
Siu, Oi-Ling, Danny Lo, Bakker, Arnold B., Shi, Kan, Chen, Wei-qing, Brough, P, Siu, OL, Lu, Chang-Qin, Lo, Danny, Chang-qin Lu, Bakker, Arnold B, Brough, Paula, Michael O'Driscoll, O’Driscoll, Michael P., Chen, WQ, Sit, C, Chen, W, Shi, K, Arnold B. Bakker, Cindy Sit, Kalliath, Thomas, Siu, Oi Ling, Jia-fang Lu, Bakker, Arnold, Phillips, David R., Thomas Kalliath, O'Driscoll, M, Oi-ling Siu, Phillips, DR, Lu, C, Siu, O, O'Driscoll, Michael, Bakker, Arnold; id_orcid, Kalliath, T, David R. Phillips, Lu, J, Phillips, David R, Bakker, AB, Lu, JF, Lo, D, Paula Brough, Sit, Cindy, O'Driscoll, Michael, Lu, Jia-fang, Kan Shi, Wei-qing Chen, Lu, CQ   +46 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Job demands-resources on digital gig platforms and counterproductive work behavior

Frontiers in Psychology
IntroductionWith the rapid expansion of digital gig platforms, counterproductive work behavior among gig workers has become increasingly prominent, adversely impacting the platform’s reputation, operational efficiency, and user experience.
Shanshan Zhao, Shanshan Zhao, Yanfeng Liu, Yanfeng Liu   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source