Results 211 to 220 of about 47,334 (259)

Kainate receptors and synaptic plasticity

Nature, 2000
Bortolotto et al.1 report that the kainate subtype of glutamate receptor is essential for the plasticity of certain types of synaptic transmission in the brain, which is of interest as these receptors were previously not thought to initiate plastic processes. In particular, a new antagonist (LY382884) was shown to act selectively against the GluR5 type
R A, Nicoll, J, Mellor, M, Frerking, D, Schmitz   +3 more
openaire   +2 more sources

Synaptic plasticity of kainate receptors

Biochemical Society Transactions, 2006
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors.
openaire   +3 more sources

Kainate induces apoptosis in neurons

Neuroscience, 1996
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainate neurotoxicity using cerebellar granule cell neurons ...
N A, Simonian, R L, Getz, J C, Leveque, C, Konradi, J T, Coyle   +4 more
openaire   +2 more sources

Kainate receptors in epilepsy and excitotoxicity

Neuroscience, 2009
Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to induce behavioral and electrophysiological seizures as well as neuropathological lesions reminiscent of those found in patients with temporal lobe epilepsy. More than a decade after the initial KA studies, molecular cloning of ionotropic glutamate receptors ...
P, Vincent, C, Mulle
openaire   +2 more sources

Kainate receptors and synaptic transmission

Progress in Neurobiology, 2003
Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors.
openaire   +2 more sources

Inhibitors of AMPA and Kainate Receptors

Current Medicinal Chemistry, 2001
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen, T B, Stensbøl, P, Krogsgaard-Larsen   +2 more
openaire   +2 more sources

Kainate receptor pharmacology and physiology

Cellular and Molecular Life Sciences (CMLS), 1999
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists.
openaire   +2 more sources

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation

Nature Neuroscience, 2017
M. Petrovic, Silvia Viana da Silva, J. Clement, L. Vyklický, C. Mulle, Inmaculada M. González‐González, J. Henley   +6 more
semanticscholar   +1 more source

Lessons from crystal structures of kainate receptors

Neuropharmacology, 2017
Stine M&phgr;llerud, K. Frydenvang, D. Pickering, J. Kastrup   +3 more
semanticscholar   +1 more source

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy.

Neurobiology of Disease, 2016
Sreekanth Puttachary, Shaunik Sharma, S. Verma, Yang Yang, Marson Putra, Achala Thippeswamy, Diou Luo, T. Thippeswamy   +7 more
semanticscholar   +1 more source