Results 191 to 200 of about 22,259 (219)
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Kainate receptors and synaptic plasticity
Nature, 2000Bortolotto et al.1 report that the kainate subtype of glutamate receptor is essential for the plasticity of certain types of synaptic transmission in the brain, which is of interest as these receptors were previously not thought to initiate plastic processes. In particular, a new antagonist (LY382884) was shown to act selectively against the GluR5 type
R A, Nicoll +3 more
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Kainate induces apoptosis in neurons
Neuroscience, 1996Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainate neurotoxicity using cerebellar granule cell neurons ...
N A, Simonian +4 more
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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen +2 more
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Kainate receptor pharmacology and physiology
Cellular and Molecular Life Sciences (CMLS), 1999Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists.
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Kainate receptors: subunits, synaptic localization and function
Trends in Pharmacological Sciences, 1999Ramesh Chittajallu +2 more
exaly