Results 181 to 190 of about 22,259 (219)
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Current Opinion in Neurobiology, 2000
Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
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Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
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Kainate receptors in the hippocampus
European Journal of Neuroscience, 2014AbstractKainate receptors (KARs) consist of a family of ionotropic glutamate receptors composed of the combinations of five subunits, GluK1–GluK5. Although KARs display close structural homology with AMPA receptors, they serve quite distinct functions.
Mario, Carta +3 more
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Comparative Antagonism of Kainate-activated Kainate and AMPA Receptors in Hippocampal Neurons
European Journal of Neuroscience, 1996 AbstractNative kainate receptors expressed by cultured hippocampal cells were studied in the whole‐cell configuration of the patch‐clamp technique by using a fast perfusion system. About 80% of the neurons expressed kainate receptors independently of the time in culture (0–4 days), which coincided with the number of cells immunoreactive for a ...
Ana V Paternain +2 more
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2010
Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
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Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
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Physiopathology of kainate receptors in epilepsy
Current Opinion in Pharmacology, 2015Kainate receptors (KARs) are tetrameric ionotropic glutamate receptors composed of the combinations of five subunits GluK1-GluK5. KARs are structurally related to AMPA receptors but they serve quite distinct functions by regulating the activity of synaptic circuits at presynaptic and postsynaptic sites, through either ionotropic or metabotropic actions.
Valérie, Crépel, Christophe, Mulle
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The Neuroscientist, 2013
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
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Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
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Role of kainate receptors in nociception
Brain Research Reviews, 2002Nociceptive nerve fibers use L-glutamate as a fast excitatory neurotransmitter and it is therefore not surprising that both, ionotropic and metabotropic glutamate receptors play pivotal roles for transmission of nociceptive information in spinal cord.
Ruth, Ruscheweyh, Jürgen, Sandkühler
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Kainate neurotoxicity and glutamate inactivation
Neuroscience Letters, 1979Dihydrokainate, an inhibitor of high affinity L-glutamate as an excitant of cat spinal neurones in vivo. This action of dihydrokainate was selective in that the effects of excitants taken up actively in vitro by CNS tissue (L-aspartate, D- and L-glutamate and L-homocysteate) were enhanced whereas those of other substances not taken up (acetylcholine, D-
D, Lodge +3 more
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Kainate receptors in epilepsy and excitotoxicity
Neuroscience, 2009Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to induce behavioral and electrophysiological seizures as well as neuropathological lesions reminiscent of those found in patients with temporal lobe epilepsy. More than a decade after the initial KA studies, molecular cloning of ionotropic glutamate receptors ...
P, Vincent, C, Mulle
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Kainate-like neurotoxicity of folates
Nature, 1981Kainic acid (KA) is one of the most powerful of a group of ‘excitotoxic’ analogues of the putative neurotransmitter glu-tamate (Glu) whose neurotoxicity may involve an excitatory mechanism mediated through glutamergic postsynaptic receptors1–8. The finding9 that neural membranes have specific sites where KA binds quite firmly and that Glu inhibits such
J W, Olney, T A, Fuller, T, de Gubareff
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