Results 151 to 160 of about 164,663 (253)

The Synergy Between a Silver‐Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage

Molecular Microbiology, EarlyView.
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun, Gracious Y. Donkor, Julius K. Narh, Grady D. Jacobson, Cade Ward, Patrick O. Tawiah, Lisa K. Polzer, Kevin A. Edwards, Kyle A. Floyd, Jan‐Ulrik Dahl   +9 more
wiley   +1 more source

Hospital-Associated Antimicrobial Resistant Bacteria on 95 Mobile Phones: An International Metagenomic "Phonome" Analysis. [PDF]

Microbiologyopen
Goldsworthy A, Olsen M, Obonyo NG, Jones P, McKirdy S, Senok A, Alghafri R, Ghemrawi R, Almheiri R, Tronstad O, Suen JY, Fraser JF, Tajouri L.   +12 more
europepmc   +1 more source

A Nutrient‐Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus

Molecular Microbiology, EarlyView.
LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley   +1 more source

A Spontaneous Mutation in tfoX Impairs Bioluminescence in Photobacterium kishitanii ANT‐2200

Molecular Microbiology, EarlyView.
A frameshift mutation in tfoX generates a truncated regulator associated with reduced lux–rib expression and low luminescence. Complementation with wild‐type tfoX restores transcription and light production, supporting a role for TfoX in regulating bioluminescence independently of quorum sensing.
Capucine Le Cam Ligier, Gwenola Simon, Charlotte Berthelier, Corinne Valette, Elisa Lefeuvre, Marc Garel, Laurie Casalot   +6 more
wiley   +1 more source

Cryo-EM structures of a MexB-MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain. [PDF]

Acta Crystallogr F Struct Biol Commun
Wang J, Tsutsumi K, Hirose M, Nakashima R, Kato T, Nishino K, Nakagawa A, Yamashita E.   +7 more
europepmc   +1 more source

The host range paradox of Meloidogyne incognita: a physiological and transcriptomic analysis of nine susceptible interactions across six plant orders

New Phytologist, EarlyView.
Phylogenetic distance of host does not explain phenotypic differences of Meloidogyne incognita parasitism at 25 dpi. Summary The plant–parasitic nematode Meloidogyne incognita is the pathogen with the broadest host range among all known biotrophic interactions.
Victor Hugo Moura de Souza, Clement Pellegrin, Vincent C. T. Hanlon, Chongjing Xia, Olaf P. Kranse, Unnati Sonawala, Priya Desikan, Beatrice Senatori, Lucie Bolell, Etienne G. J. Danchin, Lida Derevnina, Sebastian Eves‐van den Akker   +11 more
wiley   +1 more source

A novel isolated phage targeting Pseudomonas aeruginosa demonstrates therapeutic potential. [PDF]

PLoS One
Wang X, Zhang Z, Garbarino E, Chen S, Liu G, Tang H, Xie H.   +6 more
europepmc   +1 more source

The ComEA/ComEC Operon is Critical for Nitrosative Stress Tolerance by an Oral Commensal

Molecular Oral Microbiology, EarlyView.
ABSTRACT Oral commensal streptococci play a large role in mediating microbial homeostasis. Our prior work has demonstrated that hydrogen peroxide (H2O2) produced by oral commensal streptococci can react with salivary nitrite (NO2) and generate peroxynitrite (ONOO−), a potent antimicrobial.
Sara E. Edmonds, Hernan Grenett, Priscilla Grenett, Jessica A. Scoffield   +3 more
wiley   +1 more source

Host genetics shapes the recovery of the gut microbiome after antibiotic treatment: the role of the blood group related <i>B4galnt2</i> gene. [PDF]

mSystems
Čepić A, Rausch P, Geese T, Dempfle A, Grassl GA, Baines JF.   +5 more
europepmc   +1 more source

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source