Results 151 to 160 of about 178,982 (291)

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil   +7 more
wiley   +1 more source

Chemistry of kanamycin. I. Degradation products of kanamycin.

open access: yesThe Journal of antibiotics, 1957
Ogawa, Hiroshi, Itō, Teiichirō
openaire   +2 more sources

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider   +4 more
wiley   +1 more source

Chemistry of kanamycin. II. The degradation compound B of kanamycin.

open access: yesThe Journal of antibiotics, 1958
Ogawa, Hiroshi   +3 more
openaire   +3 more sources

Effect of kanamycin on calcium current of rabbit ventricular myocyte

open access: yes, 1992
의학과/박사[한글] 임상에서 감염성 질환의 치료제로 사용되고 있는 aminoglycoside 계통의 항생제 중의 하나인 kanamycin은 신장 및 청각 계통에 대한 독성 이외에 순환기계에도 장애를 초래함이 보고되었다. 즉 kanamycin의 투여 농도에 비례하여 심근의 수축력이 저하되며, 분리한 심근막에서의 Ca**++ 결합을 경쟁적으로 억제하며, 고농도 K^^+ -유발 활동전압의 크기 및 탈분극 속도를 저하시킨다는 보고 등은 ...
박국인
core  

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

open access: yesPest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier   +15 more
wiley   +1 more source

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