Results 41 to 50 of about 161,054 (247)

Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions

Molecules
G-quadruplexes (G4s) are distinctive four-stranded nucleic acid structures formed by guanine-rich sequences, making them attractive targets for drug repurposing efforts.
Gianmarco Gualtieri, Emanuele Liborio Citriniti, Roberta Rocca, Valentina Arciuolo, Jussara Amato, Antonio Randazzo, Stefano Alcaro   +6 more
doaj   +1 more source

Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications

Advanced Materials, EarlyView.
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa, Paolo Blesio, Marcial Fernandez‐Castro, Lisa Almonte, Maxence Fernandez, Mantas Liutkus, Perumal Pandurangan, Carlos Sabater, Aitor Villaverde, Manuel Melle‐Franco, Nurit Ashkenasy, Felipe Jiménez‐Ángeles, M. Carmen Morant‐Miñana, M. Reyes Calvo, Aitziber L. Cortajarena   +14 more
wiley   +1 more source

Factors affecting gene transformation in mangosteen [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2003
Factors affecting gene transformation in mangosteen (Garcinia mangostana L.) were investigated. Types of explants, strains and densities of Agrobacterium tumefaciens, and co-culture methods were examined to optimize gene transformation.
Sompong Te-chato, Vitoon Chaipakdee
doaj  

Integrating Vibrio natriegens for Photon Manipulation in Living Lighting Devices

Advanced Materials, EarlyView.
Rationalization of genetic and material engineering tools has enabled the engineering of fluorescent Vibrio natriegens (V. natriegens) to fabricate straightforward, highly emissive and stable V. natriegens‐silicones color filters for the first red‐emitting bacteria‐hybrid light‐emitting diodes. This pinpoints V. natriegens as a high‐performance protein
Stephanie Willeit, Maurice Hädrich, Philippe‐Quentin Liss, Valeria Rodriguez Espinoza, Nicklas Maximilian Foerster, Bastian Blombach, Rubén D. Costa   +6 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Theoretical Studies on Mechanism of Inactivation of Kanamycin A by 4′-O-Nucleotidyltransferase

Frontiers in Chemistry, 2019
This work is focused on mechanistic studies of the transfer of an adenylyl group (Adenoside-5′-monophosfate) from adenosine 5′-triphosphate (ATP) to a OH-4′ hydroxyl group of an antibiotic.
Sergio Martí, Agatha Bastida, Katarzyna Świderek   +2 more
doaj   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Investigation of METTL3 as an inhibitor of kanamycin-induced ototoxicity via stress granule formation

Frontiers in Pharmacology
BackgroundMethyltransferase-like 3 (METTL3), a component of the N6-methyladenosine (m6A) methyltransferase family, exhibits significant expression in HEI-OC1 cells and cochlear explants.
Yan Wu, Yan Wu, Yan Wu, Yu-Yu Huang, Yu-Yu Huang, Yu-Yu Huang, Lu-Yao Wang, Lu-Yao Wang, Lu-Yao Wang, Yan Yang, Fei-Lun Cui, Shu-Na Li, Shu-Na Li, Shu-Na Li   +13 more
doaj   +1 more source

IN VITRO AND IN VIVO SUSCEPTIBILITY OF MASTITIS PATHOGENS ISOLATED FROM BOVIN MASTITIS TO ANTIMICROBIAL DRUGS

The Iraqi Journal of Veterinary Medicine, 1992
The in vitro sensitivity testing of mastitis pathogens, associated with udder infections in cows, against 12 chemotherapeutic agents, showed that all strains (100%) tested are sensitive to gentamicin.
A. A. Yass
doaj   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source