Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation. [PDF]
PLoS ONE, 2017 Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair.
Benjamin M Laitman +4 more
doaj +5 more sources
Karyopherins regulate nuclear pore complex barrier and transport function [PDF]
Journal of Cell Biology, 2017 Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Larisa E. Kapinos +3 more
core +9 more sources
Identification of karyopherin α1 and α7 interacting proteins in porcine tissue. [PDF]
PLoS ONE, 2012 Specialized trafficking systems in eukaryotic cells serve a critical role in partitioning intracellular proteins between the nucleus and cytoplasm. Cytoplasmic proteins (including chromatin remodeling enzymes and transcription factors) must gain access ...
Ki-Eun Park +5 more
doaj +3 more sources
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone [PDF]
eLife, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil +9 more
doaj +3 more sources
Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1 [PDF]
Scientific ReportsIn eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel +3 more
doaj +2 more sources
Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas [PDF]
Frontiers in Veterinary ScienceExtraskeletal osteosarcoma (EOS) is a malignant tumor producing bone matrix and/or chondroid material, without direct attachment to bone or periosteum.
Leonardo Leonardi +3 more
doaj +2 more sources
Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis [PDF]
Frontiers in NeuroscienceCytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS).
Manpreet Singh Atwal +20 more
doaj +2 more sources
Take your mother’s ferry: preimplantation embryo development requires maternal karyopherins for nuclear transport [PDF]
The Journal of Clinical Investigation, 2023 The genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this issue of the JCI, Wang, Miyamoto, et
Momal Sharif +2 more
doaj +2 more sources
Preliminary investigation on the correlation between karyopherin alpha 4 and acute cerebral infarction. [PDF]
CytojournalChu J, Ren N, Xie C.
europepmc +2 more sources
Transportin-1: A Nuclear Import Receptor with Moonlighting Functions
Frontiers in Molecular Biosciences, 2021 Transportin-1 (Trn1), also known as karyopherin-β2 (Kapβ2), is probably the best-characterized nuclear import receptor of the karyopherin-β family after Importin-β, but certain aspects of its functions in cells are still puzzling or are just recently ...
Allegra Mboukou +5 more
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