Results 101 to 110 of about 10,614 (241)

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

Asian Journal of Andrology, 2015
The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo, Josep Maria Estanyol, Josep Lluis Ballescà, Rafael Oliva   +3 more
doaj   +1 more source

Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling

Journal of Ovarian Research, 2021
Background Karyopherin α-2 (KPNA2) is a member of karyopherin family, which is proved to be responsible for the import or export of cargo proteins. Studies have determined that KPNA2 is associated with the development and prognosis of various cancers ...
Xiangrong Cui, Honghong Wang, Xueqing Wu, Kai Huo, Xuan Jing   +4 more
doaj   +1 more source

Karyopherin-βs play a key role as a phase separation regulator [PDF]

, 2021
Takuya Yoshizawa, Lin Guo
openalex   +1 more source

Elucidation of the ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function [PDF]

, 2014
Viral pathogenesis in the infected cell is a balance between antiviral responses and subversion of host-cell processes. Many viral proteins specifically interact with host-cell proteins to promote virus biology.
Altamirano A. A., Boulon S., David Matthews, Dodson A. W., Ebihara H., Emmott E., Feldmann F., Huggins J., Isabel García-Dorival, Iwasa A., John N. Barr, Jonathan Wastling, Jourdan S. S., Julian A. Hiscox, Karuppannan A. K., Lee M. S., Marsh G. A., Mateo M., Mateo M., Mateo M., Mateo M., Miles Carroll, Nanbo A., Olivier Touzelet, Pichlmair A., Ramanan P., Randall R. E., Reid S. P., Reid S. P., Roger Hewson, Smith D. R., Spurgers K. B., Stuart Armstrong, Stuart Dowall, Trinkle-Mulcahy L., Trombley A. R., Volchkov V. E., Watanabe S., Weingartl H. M., Weining Wu, Wu W., Zhang A. P.   +41 more
core   +1 more source

Karyopherins in nuclear transport of homeodomain proteins during development

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking.
Ye, Wenduo, Lin, Wenbo, Tartakoff, Alan M., Tao, Tao   +3 more
openaire   +3 more sources

New insights into the regulation of cholesterol efflux from the sperm membrane

Asian Journal of Andrology, 2015
Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
doaj   +1 more source

From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR [PDF]

, 2015
Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable.
Packham, Sylvia
core   +1 more source

MiR‐20a‐5p Inhibits Bladder Cancer Proliferation and Migration by Targeting KPNA2

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis and searching for new prognostic markers and therapeutic targets are important for improving patient prognosis.
Shuai Ye, Cen Liufu, Cong Yin, Tao Zhu, Jinqing He, Yuanyuan Tian, Yan Wang, Bentao Shi   +7 more
wiley   +1 more source

Nuclear Transport of Yeast Proteasomes

Frontiers in Molecular Biosciences, 2019
Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP).
Petra Wendler, Cordula Enenkel
doaj   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, Volume 47, Issue 7, July 2025.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source