Results 11 to 20 of about 10,614 (241)

Karyopherin α deficiency contributes to human preimplantation embryo arrest

The Journal of Clinical Investigation, 2023
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang   +31 more
doaj   +3 more sources

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: A novel path to cancer prevention. [PDF]

Int J Cancer
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Hajirahimkhan A, Bartom ET, Chung CH, Guo X, Berkley K, Hosseinibarkooie S, Assadi Z, Weng SHS, Moellering R, Lee O, Chen R, Cho W, Chandrasekaran S, Clare SE, Khan SA.   +14 more
europepmc   +2 more sources

Karyopherin abnormalities in neurodegenerative proteinopathies [PDF]

Brain, 2021
Abstract Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, α-synuclein, TAR DNA binding protein-43, fused in sarcoma and mutant ...
Terouz Pasha, Anna Zatorska, Daulet Sharipov, Boris Rogelj, Tibor Hortobágyi, Frank Hirth   +5 more
openaire   +3 more sources

KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus. [PDF]

Cancer Med
ABSTRACT Background Abnormal protein localization due to disrupted nucleoplasmic transport is common in tumor cells, but its mechanisms are not well understood. Nuclear pore complexes and nuclear transporter proteins are crucial for protein transport between the nucleus and cytoplasm.
Hu Y, Zhou J, Ling X, Zhao K, Huang P, Gao M, Li X, Sun M, Zou Y, Feng G.   +9 more
europepmc   +2 more sources

Birth, Death, and Replacement of Karyopherins in Drosophila [PDF]

Molecular Biology and Evolution, 2011
Nucleocytoplasmic transport is a broadly conserved process across eukaryotes. Despite its essential function and conserved mechanism, components of the nuclear transport apparatus have been implicated in genetic conflicts in Drosophila, especially in the male germ line. The best understood case is represented by a truncated RanGAP gene duplication that
Nitin Phadnis, Emily Hsieh, Harmit S. Malik   +2 more
openalex   +3 more sources

Kapβ2 Reverses Sevoflurane-Induced Hydrogel Phase Transition of hnRNPA2/B1-SG in Hypoxic Primary Rat Hippocampal Neurons. [PDF]

CNS Neurosci Ther
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Zhang M, Wang X, Jia F, Yang C, Wang Z, Liao H, Zhang L, Xin X, Wang H.   +8 more
europepmc   +2 more sources

Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24

Viruses, 2023
Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less pathogenic, and Reston (RESTV) is not known to cause a disease in humans.
Palaniappan Ramanathan, Bersabeh Tigabu, Rodrigo I. Santos, Philipp A. Ilinykh, Natalia Kuzmina, Olivia A. Vogel, Naveen Thakur, Hamza Ahmed, Chao Wu, Gaya K. Amarasinghe, Christopher F. Basler, Alexander Bukreyev   +11 more
doaj   +1 more source

Karyopherins and condensates

Current Opinion in Cell Biology, 2020
Several aggregation-prone RNA-binding proteins, including FUS, EWS, TAF15, hnRNP A1, hnRNP A2, and TDP-43, are mutated in neurodegenerative diseases. The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these
Charis E. Springhower, Michael K. Rosen, Yuh Min Chook   +2 more
openaire   +2 more sources

The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking

Viruses, 2021
Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison, Cassandra T. David, Stephen M. Rawlinson, Gregory W. Moseley   +3 more
doaj   +1 more source

Karyopherins in nuclear pore biogenesis [PDF]

The Journal of Cell Biology, 2002
The mechanisms that govern the assembly of nuclear pore complexes (NPCs) remain largely unknown. Here, we have established a role for karyopherins in this process. We show that the yeast karyopherin Kap121p functions in the targeting and assembly of the nucleoporin Nup53p into NPCs by recognizing a nuclear localization signal (NLS) in Nup53p.
C. Patrick Lusk, Taras Makhnevych, Marcello Marelli, John D. Aitchison, Richard W. Wozniak   +4 more
openaire   +1 more source