Results 71 to 80 of about 10,614 (241)

Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng, Xu Zhang, Yulu Jiang, Yuxiang Luo, Zuao Wang, Xiaohong Du, Leifeng Chen   +6 more
wiley   +1 more source

Varicocele and testicular function

Asian Journal of Andrology, 2015
Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility.
Alexander W Pastuszak, Run Wang
doaj   +1 more source

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. [PDF]

PLoS ONE, 2012
BackgroundProtein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells are either bacterial pathogenic toxins or endogenous ...
Simone Di Paola, Massimo Micaroni, Giuseppe Di Tullio, Roberto Buccione, Maria Di Girolamo   +4 more
doaj   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, Volume 5, Issue 11, November 2025.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Antagonism of STAT3 signalling by Ebola virus.

PLoS Pathogens, 2021
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important to ...
Angela R Harrison, Shawn Todd, Megan Dearnley, Cassandra T David, Diane Green, Stephen M Rawlinson, Gough G Au, Glenn A Marsh, Gregory W Moseley   +8 more
doaj   +1 more source

ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells

Current Issues in Molecular Biology, 2023
Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant cancer cells.
Kota Sato, Hironori Yoshino, Yoshiaki Sato, Manabu Nakano, Eichi Tsuruga   +4 more
doaj   +1 more source

The HIV capsid mimics karyopherin engagement of FG-nucleoporins. [PDF]

Nature
AbstractHIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central
Dickson CF, Hertel S, Tuckwell AJ, Li N, Ruan J, Al-Izzi SC, Ariotti N, Sierecki E, Gambin Y, Morris RG, Towers GJ, Böcking T, Jacques DA.   +12 more
europepmc   +4 more sources

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth [PDF]

Oncogene, 2019
Prostate cancer (PCa) initiation and progression requires activation of numerous oncogenic signaling pathways. Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role of nuclear transporter proteins in PCa progression has not been well defined.
Yang, Jian, Gsuo, Yuqi, Lu, Cuijie, Zhang, Ruohan, Wang, Yaoyu, Luo, Liang, Zhang, Yanli, Chu, Catherine H, Wang, Katherine J, Obbad, Sabrine, Yan, Wenbo, Li, Xin   +11 more
openaire   +2 more sources