Results 81 to 90 of about 10,614 (241)
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. [PDF]
, 2007 Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy.
Bose, Ron +5 more
core +1 more source
Clinical and Translational Science, Volume 18, Issue 10, October 2025.ABSTRACT Triple‐negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited targeted therapeutic options. Exosomes, small membrane vesicles secreted by cells, play a crucial role in intercellular communication and material exchange. However, the role of exosome‐related genes (ERGs) in TNBC remains unclear.
Yuan Zhang +5 more
wiley +1 more source
Nuclear import by karyopherin-βs: Recognition and inhibition
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Proteins in the karyopherin-β family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of the 14S. cerevisiae karyopherin-βs mediate nuclear import through recognition of nuclear localization signals or NLSs in their cargos.
Chook, Yuh Min, Süel, Katherine E.
openaire +2 more sources
The Kap60-Kap95 Karyopherin Complex Directly Regulates Phosphatidylcholine Synthesis [PDF]
Journal of Biological Chemistry, 2009 Phosphatidylcholine is the major phospholipid in eukaryotic cells. There are two main pathways for the synthesis of phosphatidylcholine: the CDP-choline pathway present in all eukaryotes and the phosphatidylethanolamine methylation pathway present in mammalian hepatocytes and some single celled eukaryotes, including the yeast Saccharomyces cerevisiae ...
Melissa A, MacKinnon +5 more
openaire +2 more sources
Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein
Journal of VirologyAdeno-associated viruses (AAVs) are the most extensively researched viral vectors for gene therapy globally. The AAV viral protein 1 (VP1) N-terminus controls the capsid’s ability to translocate into the cell nucleus; however, the exact mechanism of this
Mikayla Hoad +5 more
doaj +1 more source
Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis
Asian Journal of Andrology, 2015 Ezrin, radixin, moesin and merlin (ERM) proteins are highly homologous actin-binding proteins that share extensive sequence similarity with each other.
N Ece Gungor-Ordueri +2 more
doaj +1 more source
Advanced Science, Volume 12, Issue 36, September 25, 2025.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling
Journal of VirologyNumerous species in the genus Flavivirus have been identified to pose serious threats to public health. Most of them have developed evasion strategies to counteract antiviral activity triggered by type I interferon (IFN-I), making prevention and control ...
Ji Zhang +13 more
doaj +1 more source
Asian Journal of Andrology, 2015 Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland +5 more
doaj +1 more source
Interactome mapping reveals the evolutionary history of the nuclear pore complex [PDF]
, 2016 The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Brillantes, Marc +7 more
core +5 more sources