Results 91 to 100 of about 6,766 (259)
Small Science, Volume 5, Issue 11, November 2025.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source
Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad
Cell & Bioscience, 2011 Smad proteins are the intracellular mediators of transforming growth factor β (TGF-β) signaling. Smads function as transcription factors and their activities require carboxyl-terminal phosphorylation by TGF-β receptor kinases which are embedded in the ...
Chen Xiaochu, Xu Lan
doaj +1 more source
A Proteomic Survey of Host and Virus Reveals Differential Dynamics [PDF]
, 2014 We studied the dynamics of the proteome of influenza virus A/PR/8/34 (H1N1) infected Madin-Darby canine kidney cells up to 12 hours post infection by mass spectrometry based quantitative proteomics using the approach of stable isotope labeling by amino ...
Flöttmann, Max +7 more
core +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu +18 more
wiley +1 more source
Inhibition of Karyopherin beta 1 suppresses prostate cancer growth [PDF]
Oncogene, 2019 Prostate cancer (PCa) initiation and progression requires activation of numerous oncogenic signaling pathways. Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role of nuclear transporter proteins in PCa progression has not been well defined.
Yang, Jian +11 more
openaire +2 more sources
Importins and Exportins Regulating Allergic Immune Responses
Mediators of Inflammation, 2014 Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo ...
Ankita Aggarwal, Devendra K. Agrawal
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 The building of the brain is a multistep process that requires the coordinate expression of thousands of genes and an intense nucleocytoplasmic transport of RNA and proteins.
Gerry Nganou +17 more
doaj +1 more source
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. [PDF]
, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Brautigam, Chad A +9 more
core +1 more source
Domains of Gln3p Interacting with Karyopherins, Ure2p, and the Target of Rapamycin Protein*
Journal of Biological Chemistry, 2003 Gln3p is a GATA-type transcription factor responsive to the quality of nitrogen and carbon. In preferred nitrogen such as glutamine, Gln3p is phosphorylated and sequestered in the cytoplasm in a manner that is dependent on the target of rapamycin (TOR ...
J. Carvalho, X. F. S. Zheng
semanticscholar +1 more source
Clinical and Translational Science, Volume 18, Issue 10, October 2025.ABSTRACT Triple‐negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited targeted therapeutic options. Exosomes, small membrane vesicles secreted by cells, play a crucial role in intercellular communication and material exchange. However, the role of exosome‐related genes (ERGs) in TNBC remains unclear.
Yuan Zhang +5 more
wiley +1 more source