Results 101 to 110 of about 6,766 (259)

Nuclear import by karyopherin-βs: Recognition and inhibition

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Proteins in the karyopherin-β family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of the 14S. cerevisiae karyopherin-βs mediate nuclear import through recognition of nuclear localization signals or NLSs in their cargos.
Chook, Yuh Min, Süel, Katherine E.
openaire   +2 more sources

The Kap60-Kap95 Karyopherin Complex Directly Regulates Phosphatidylcholine Synthesis [PDF]

Journal of Biological Chemistry, 2009
Phosphatidylcholine is the major phospholipid in eukaryotic cells. There are two main pathways for the synthesis of phosphatidylcholine: the CDP-choline pathway present in all eukaryotes and the phosphatidylethanolamine methylation pathway present in mammalian hepatocytes and some single celled eukaryotes, including the yeast Saccharomyces cerevisiae ...
Melissa A, MacKinnon, Amy J, Curwin, Gerard J, Gaspard, Alison B, Suraci, J Pedro, Fernández-Murray, Christopher R, McMaster   +5 more
openaire   +2 more sources

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. [PDF]

, 2013
Like ubiquitin, the small ubiquitin-related modifier (SUMO) proteins can form oligomeric chains, but the biological functions of these superstructures are not well understood. Here, we created mutant yeast strains unable to synthesize SUMO chains (smt3(
Andrews, Brenda J, Boone, Charles, Brown, Grant W, Costanzo, Michael, Giaever, Guri, Johnson, Erica S, Lewicki, Megan C, Nislow, Corey, Raught, Brian, Srikumar, Tharan, Tkach, Johnny M, Tsui, Kyle, van Bakel, Harm   +12 more
core   +2 more sources

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights [PDF]

, 2013
Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is essential for genomic integrity, has been shown to be phosphorylated on ...
Adams, Anna Erdei, Anna Magyar, Beeckmans, Beáta G. Vértessy, Bostjan Kobe, Bozóky, Békési, Chen, Cowtan, Duncan, Emsley, Enikő Takács, Enquist-Newman, Falces, Fontes, Fontes, Fontes, Fornerod, Fruzsina Babos, Gadsden, Galperin, Gergely Róna, Geymonat, Görlich, Hagen, Harreman, Hennekes, Huynh, Ikuta, Ildikó Scheer, Jans, Jans, Jans, Jaquenoud, Judit Tóth, Kabsch, Kaffman, Koehler, Kosugi, Kovári, Ladner, Ladner, Ladner, Lange, Lee, Liku, László Buday, MacFarlane, Marfori, Marfori, Mary Marfori, McCoy, McPhillips, Merényi, Mol, Moll, Muha, Muha, Máté Borsos, Nagy, Nardozzi, Németh-Pongrácz, Pecsi, Pecsi, Poon, Pécsi, Sidorova, Stephen, Tagawa, Takács, Takács, Tarrant, Tinkelenberg, Tóth, Varga, Vértessy, Winn, Zhou, Zoltán Bozóky   +79 more
core   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, Volume 12, Issue 35, September 18, 2025.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu, Yongyi Xie, Wenjie Chen, Wei Deng   +3 more
wiley   +1 more source

Epstein–Barr Virus Nuclear Antigen-1 Binds to Nuclear Transporter Karyopherin α1/NPI-1 in Addition to Karyopherin α2/Rch1

Virology, 2000
We searched for cellular proteins that interact with Epstein-Barr (EBV) virus nuclear antigen-1, which is a latent EBV origin-binding protein detected in all EBV latently infected cells and essential for maintenance of the latent EBV genome, by a yeast two-hybrid screening of a B lymphocyte cDNA library in this study.
Ito, Sayuri, Ikeda, Masato, Kato, Noriko, Matsumoto, Akiko, Ishikawa, Yuko, Kumakubo, Satomi, Yanagi, Kazuo   +6 more
openaire   +2 more sources

Determining Factors Influencing Nuclear Envelope and Nuclear Pore Complex Structure. [PDF]

, 2013
The cell’s nuclear envelope (NE) has pores that are stabilized by nuclear pore complexes (NPC), large proteinaceous structures whose function is to mediate transport between the nucleus and cytoplasm.
Gouni, Sushanth
core   +1 more source

From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR [PDF]

, 2015
Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable.
Packham, Sylvia
core   +1 more source