Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury. [PDF]
J Orthop Sports Med, 2023 Rotator Cuff Tendinopathies (RCT) are debilitating conditions characterized by alterations in the extracellular matrix (ECM) of the shoulder tendon, resulting in pain, discomfort, and functional limitations.
Diaz C, Thankam FG, Agrawal DK.
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Changing expression and subcellular distribution of karyopherins during murine oogenesis [PDF]
Reproduction, 2015 Bettina P. Mihalas +4 more
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The Eliminated Negative Charge at NLS increases the PAK I Binding to Karyopherins [PDF]
, 2016 Tania Iouk, Ursula Oberholzer
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Charge of karyopherins and nuclear FG-Nups are key ingredients of nucleocytoplasmic transport. [PDF]
Biophys JMishra A, Van der Giessen E, Onck PR.
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Karyopherin abnormalities in neurodegenerative proteinopathies [PDF]
Brain, 2021 Abstract Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, α-synuclein, TAR DNA binding protein-43, fused in sarcoma and mutant ...
Terouz Pasha +5 more
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Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation
PLOS ONE, 2017 Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the genome.
Benjamin M. Laitman +4 more
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Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier. [PDF]
Nat Cell BiolNuclear pore complexes (NPCs) mediate selective exchange of macromolecules between the nucleus and cytoplasm, but the organization of their transport barrier has been a matter of debate.
Kozai T +20 more
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Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells. [PDF]
PLoS ONE, 2013 Karyopherins are transporters involved in the bidirectional, selective and active transport of macromolecules through nuclear pores. Importin-β1 is the paradigm of karyopherins and, together with its cargo-adapter importin-α, mediates the general nuclear
Oier Etxebeste +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 1996 Cordula Enenkel +2 more
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CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan +38 more
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