Results 41 to 50 of about 6,766 (259)

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

Bio-Protocol, 2020
Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste, Thomas Vercruysse, Philip Van Damme, Ludo Van Den Bosch, Dirk Daelemans   +4 more
doaj   +1 more source

Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer

Oncology, 2022
<b><i>Introduction:</i></b> Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. Although high KPNA2 expression was associated with poor prognosis in solid tumors, the relationship between KPNA2 and KPNB1 ...
Yoshihito Ohhara, Ichiro Kinoshita, Akira Suzuki, Makoto Imagawa, Jun Taguchi, Takuro Noguchi, Satoshi Takeuchi, Yasushi Shimizu, Hideyuki Seki, Junichi Suzuki, Hirotoshi Dosaka-Akita   +10 more
openaire   +2 more sources

A survey of the specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport

Nucleus, 2023
Selective transport through the nuclear pore complex (NPC) depends on the dynamic binding of FG-repeat containing nucleoporins, the FG-nups, with each other and with Karyopherins (Kaps).
Elizabeth C. Riquelme Barrientos, Tegan A. Otto, Sara N. Mouton, Anton Steen, Liesbeth M. Veenhoff   +4 more
doaj   +1 more source

Directionality of nucleocytoplasmic transport of the retroviral gag protein depends on sequential binding of karyopherins and viral RNA

Proceedings of the National Academy of Sciences of the United States of America, 2010
Nicole Gudleski, John M. Flanagan, Eileen P. Ryan, Maria C. Bewley, Leslie J. Parent   +4 more
openalex   +3 more sources

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Modulation of Histone Deposition by the Karyopherin Kap114 [PDF]

Molecular and Cellular Biology, 2005
The nuclear import of histones is a prerequisite for the downstream deposition of histones to form chromatin. However, the coordinate regulation of these processes remains poorly understood. Here we demonstrate that Kap114p, the primary karyopherin/importin responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones
Nima Mosammaparast, Brian C. Del Rosario, Lucy F. Pemberton   +2 more
openalex   +3 more sources

A karyopherin acts in localized protein synthesis [PDF]

Cell Cycle, 2010
Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and mRNA targeting.
Veenhoff, Liesbeth M., Meinema, Anne C., Poolman, Bert   +2 more
openaire   +2 more sources

Intermolecular disulfide bonds among nucleoporins regulate karyopherin-dependent nuclear transport [PDF]

Journal of Cell Science, 2013
Disulfide (S-S) bonds play important roles in the regulation of protein function and cellular stress responses. In this study, we demonstrate that distinct sets of nucleoporins (Nups), components of the nuclear pore complex (NPC), form S-S bonds and regulate nuclear transport through the NPC.
Shige H. Yoshimura, Shotaro Otsuka, Masahiro Kumeta, Mariko Taga, Kunio Takeyasu   +4 more
openalex   +4 more sources

The IMPORTance of the Nucleus during Flavivirus Replication

Viruses, 2017
Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever.
Adam J. Lopez-Denman, Jason M. Mackenzie
doaj   +1 more source

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy [PDF]

, 2016
YesTumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function.
Bethany Raynor, El-Habib Dakir, Matchett, Mohamed El-Tanani, Richard Morgan, Talarico, Vincent   +6 more
core   +2 more sources