Results 61 to 70 of about 6,766 (259)

In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis

Scientific Reports, 2017
The central channel of the nuclear pore complex (NPC) is occupied by non-structured polypeptides with a high content of Phe-Gly (FG) motifs. This protein-rich environment functions as an entropic barrier that prevents the passage of molecules, as well as
Hide A. Konishi, Suguru Asai, Tomonobu M. Watanabe, Shige H. Yoshimura   +3 more
doaj   +1 more source

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

ChemBioChem, 2015
We describe the synthesis of a library of 11 638 N‐alkylglycine peptoid trimers in a positional scanning format with adjustment of reaction conditions to account for different reactivities of the monomer building blocks. Evaluation of the library by high‐
Glòria Vendrell-Navarro, F. Rúa, J. Bujons, A. Brockmeyer, P. Janning, Slava Ziegler, A. Messeguer, H. Waldmann   +7 more
semanticscholar   +1 more source

MiR-20a-5p Inhibits Bladder Cancer Proliferation and Migration by Targeting KPNA2. [PDF]

J Cell Mol Med
ABSTRACT Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis and searching for new prognostic markers and therapeutic targets are important for improving patient prognosis.
Ye S, Liufu C, Yin C, Zhu T, He J, Tian Y, Wang Y, Shi B.   +7 more
europepmc   +2 more sources

A Role for the Karyopherin Kap123p in Microtubule Stability [PDF]

Traffic, 2009
Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule‐destabilizing drugs.
Christopher, Ptak, Andrea M, Anderson, Robert J, Scott, David, Van de Vosse, Richard S, Rogers, Yaroslav, Sydorskyy, John D, Aitchison, Richard W, Wozniak   +7 more
openaire   +2 more sources

Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex. [PDF]

PLoS Computational Biology, 2011
The nuclear pore complex (NPC) regulates molecular traffic across the nuclear envelope (NE). Selective transport happens on the order of milliseconds and the length scale of tens of nanometers; however, the transport mechanism remains elusive. Central to
Ruhollah Moussavi-Baygi, Yousef Jamali, Reza Karimi, Mohammad R K Mofrad   +3 more
doaj   +1 more source

Pore timing:the evolutionary origins of the nucleus and nuclear pore complex [PDF]

, 2019
The name “eukaryote” is derived from Greek, meaning “true kernel”, and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria ...
A Noble, A O'Reilly, A Ori, A Pittis, A Poole, A Spang, A von Appen, C Klinger, D Devos, D Devos, D Lin, E Arakel, E Szathmáry, F Alber, G Dey, G Holzer, H Asakawa, J Cronshaw, J Dacks, J Dacks, J DeGrasse, J Fischer, J Gomez-Cavazos, J Holden, J Kosinski, K Knockenhauer, K Leung, K Tamura, K Zaremba-Niedzwiedzka, M Beck, M Beck, M D'Angelo, M Eibauer, M Faini, M Field, M Field, M Field, M Iwamoto, M Paraan, M Raices, M Robinson, M Rout, M Rout, N Yutin, P Sampathkumar, R Hayama, R Teimer, S Dodonova, S Fath, S Kim, S Mosalaganti, S Obado, S Obado, T Jovanovic-Talisman, T Ritterhoff, T Stuwe, V Sakin, W Martin, W Martin, Y Bykov   +59 more
core   +3 more sources

Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport

Molecular Biology of the Cell, 2014
The subcellular distribution of yeast β-importins inverts upon acute glucose deprivation, likely due to collapse of the RanGTP nuclear–cytoplasmic gradient.
Hsiao-Yun Huang, A. Hopper
semanticscholar   +1 more source

Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

Cells, 2019
Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have ...
Tanner M. Tessier, Mackenzie J. Dodge, Martin A. Prusinkiewicz, Joe S. Mymryk   +3 more
doaj   +1 more source

Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif. [PDF]

PLoS ONE, 2011
PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola, William J McCormack, Michelle A Morrin, Wayne J Higgins, Denise M Fox, D Margaret Worrall   +5 more
doaj   +1 more source