Results 71 to 80 of about 6,766 (259)

Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]

, 2015
The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL, Mofrad, MRK, Peyro, M, Soheilypour, M   +3 more
core   +2 more sources

Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity [PDF]

International Journal of Molecular Sciences, 2021
Background: Nuclear protein-1 (NUPR1, also known as p8/Com-1) is a transcription factor involved in the regulation of cellular stress responses, including serum starvation and drug stimulation. Methods: We investigated the mechanism of NUPR1 nuclear translocation involving karyopherin β1 (KPNB1), using a single-molecule binding assay and confocal ...
Chanhee Park, Jiwon Oh, Won Mo Lee, Hye Ran Koh, Uy Dong Sohn, Seung Wook Ham, Kyungsoo Oh   +6 more
openaire   +3 more sources

Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]

, 2019
Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E., Nabeel-Shah, Syed, Kanwal, Ashraf, Saettone, Alejandro, Garg, Jyoti, Derynck, Joanna, Lambert, Jean-Philippe, Fillingham, Jeffrey   +7 more
core   +1 more source

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2013
Background We recently reported that a bifunctional nuclear transport modifier (NTM), cSN50.1 peptide, reduced atherosclerosis, plasma cholesterol, triglycerides, and glucose along with liver fat and inflammatory markers, in a murine model of familial ...
J. Zienkiewicz, Amy Armitage, J. Hawiger
semanticscholar   +1 more source

Karyopherin α deficiency contributes to human preimplantation embryo arrest

Journal of Clinical Investigation, 2023
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed. Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene-based burden ...
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang   +31 more
openaire   +3 more sources

The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency

Molecular Systems Biology, 2007
Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin‐α (Impα), which links the cargo to a karyopherin, Importin‐β (Impβ). The reason for the existence of
Greg Riddick, Ian G Macara
doaj   +1 more source

Rtp1p Is a Karyopherin-Like Protein Required for RNA Polymerase II Biogenesis [PDF]

, 2013
The assembly and nuclear transport of RNA polymerase II (RNA pol II) are processes that require the participation of many auxiliary factors. In a yeast genetic screen, we identified a previously uncharacterized gene, YMR185w (renamed RTP1), which encodes
Ausubel FM, Boulon S, Boulon S, Burns N, Chook YM, Cingolani G, Cook AG, Cramer P, Czeko E, Edwards AM, Estruch F, Forget D, Garí E, Gavin AC, Giaever G, Graumann J, Görlich D, Imasaki T, Juanes MA, Kakihara Y, Kimura M, Krogan NJ, Lau D, Neville M, Pascual-García P, Peiró-Chova L, Peiró-Chova L, Pemberton LF, Reyes-Pardo H, Soriano-Carot M, Staresincic L, Strahm Y, Te J, Watanabe M, Wild T, Zhao R, Zhao R   +36 more
core   +1 more source

Recognition of nuclear targeting signals by Karyopherin-β proteins [PDF]

Current Opinion in Structural Biology, 2010
The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, only three classes of nuclear localization and export signals, or NLSs and NESs, have been characterized. The short basic classical-NLS was first discovered in the 1980s and
Darui, Xu, Alicia, Farmer, Yuh Min, Chook   +2 more
openaire   +2 more sources

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]

, 2010
Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet, Bates, Bennett, Bhakar, Blahos, Caviston, Chen, Cho, Colin, Colomer, Dragatsis, Dunkley, Edoardo Marcora, Engelender, Fagerlund, Fridmacher, Gauthier, Graham, Gray, Gutekunst, Hanz, Harkiolaki, Hayden, Hering, Hickey, Hunt, Imarisio, Jordan, Joshi, Kaltschmidt, Kaltschmidt, Kaltschmidt, Kennedy, Korkin, Kornau, Leavitt, Leavitt, Li, Li, Li, Lipsky, Ma, Marcora, Marini, Marini, Mary B. Kennedy, Mattson, Meffert, Meffert, Menalled, Mikenberg, Mosammaparast, Otis, Patterson, Perlson, Shimojo, Simmons, Song, Strand, Sun, Suzuki, Takano, The Huntington's Disease Collaborative Research Group, Thompson, Tian, Towbin, Trushina, Velier, Wang, Wellmann, Xie, Zhang, Zuccato, Zuccato, Zuccato   +74 more
core   +4 more sources

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. [PDF]

PLoS Genetics, 2015
Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop.
A Reum Jang, Katarina Moravcevic, Lino Saez, Michael W Young, Amita Sehgal   +4 more
doaj   +1 more source