Results 111 to 120 of about 17,716 (217)

Sodium butyrate activates the KATP channels to regulate the mechanism of Parkinson's disease microglia model inflammation

Immunity, Inflammation and Disease
Background Parkinson's disease (PD) is a common neurodegenerative disorder. Microglia‐mediated neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. Activation of adenosine triphosphate (ATP)‐sensitive potassium
Ye Xu, Laofu Wen, Yunyi Tang, Zhenqiang Zhao, Miaojing Xu, Tan Wang, Zhibin Chen   +6 more
doaj   +1 more source

Discovery and characterization of a novel KATP channel pharmacochaperone

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM structure of the KATP channel. Additionally, I functionally characterized the effects
Elsheikh, Assmaa
core   +1 more source

Metabolic Seizure Resistance via BAD and KATP Channels

, 2016
On a ketogenic diet, ketone bodies provide an alternative fuel, replacing much of the glucose used ordinarily by the brain. This switch is thought to underlie its anticonvulsant effects.
Gary Yellen, Nika N. Danial, Juan Ramón Martínez-François   +2 more
core   +1 more source

KATP channel controls LPS-induced MUC5AC overexpression in vivo

, 2020
Glybenclamide; Hypersecretion; Inflammation; KATP channel; MUC5AC ...
송경섭
core  

KATP-Associated Hyperinsulinism [PDF]

, 2020
openaire   +1 more source

Gating Mechanism of KATP Channels [PDF]

The Journal of General Physiology, 2003
D. Enkvetchakul, C.G. Nichols
openaire   +1 more source

Co-occurrence of Loss-of-Function GCK and ABCC8 Variants in a Pedigree With a Spectrum of Dysglycemia. [PDF]

Diabetes
Saint-Martin C, ElSheikh A, Jacqueminet S, Arnoux JB, Ciangura C, Bellanné-Chantelot C, Shyng SL.   +6 more
europepmc   +1 more source

Electrophysiological tests on recombinant cardiovascular KATP-channels: effects of nukleotids, novel KATP-channelopeners and blockers

, 2005
In dieser Arbeit wurden die Effekte von Nukleotiden, KATP-Kanalblockern und -öffnern auf die Aktivität v. a. der rekombinanten kardiovaskulären KATP-Kanäle mit der patch-clamp-Technik untersucht.
Lange, Ulf
core  

Potassium channel-targeted therapy in reducing vascular complications in diabetes mellitus: novel insights. [PDF]

Front Pharmacol
Rajkovic J, Ribic A, Rekovic L, Gostimirovic M, Bukarica A, Terzic D, Gojkovic-Bukarica L.   +6 more
europepmc   +1 more source

[Exogenous nitric oxide suppresses K _ATP channel activity through S-nitrosylation]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Wang X, Zhang Y, Hu W, Hao X.
europepmc   +1 more source