Results 101 to 110 of about 17,716 (217)

The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

Pharmacogenomics and Personalized Medicine, 2010
Veronica Lang, Peter E LightDepartment of Pharmacology and Alberta Diabetes Institute, Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Neonatal diabetes mellitus (NDM)
Veronica Lang, Peter E Light
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Evidence for functional ATP-sensitive (KATP) potassium channels in human and equine articular chondrocytes

, 2007
SummaryObjectiveChondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must possess a number of mechanisms to detect and respond to alterations in the metabolic state of ...
Womack, M.D, R. Barrett-Jolley, M.D. Womack, Barrett-Jolley, R., Mobasheri, A, Mobasheri, A., C.A. Moskaluk, Nash, A.I, Nash, AI, Gent, T.C., Moskaluk, CA, Moskaluk, C.A., T.C. Gent, Gent, TC, A. Mobasheri, Womack, M.D., A.I. Nash, Gent, T.C, Moskaluk, C.A, Womack, MD, Nash, A.I., Barrett-Jolley, R   +21 more
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Closure by iptakalim, a cardiovascular KATP channel opener, of rat pancreatic β-cell KATP channels and its molecular basis [PDF]

application/pdfDiabetes mellitus is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both.
Wu, Jie, Wakui, Makoto, Misaki, Naoko, Suga, Sechiko, Lin, Yu-Fung, Mao, Xia   +5 more
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Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
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Investigation Of The Role Of The KATP Channel In Vascular Hyporeactivity In Sepsis [PDF]

, 2017
The lack of responsiveness of vascular smooth muscle cells (VSMCs) to vasopressor catecholamines is termed vascular hyporeactivity. Vascular hyporeactivity is an important component of sepsis.
Buckley, James Francis
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Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells

, 1995
ATP-sensitive K+ (KATP) channels are thought only to open during conditions of metabolic impairment (e.g., myocardial ischemia). However, the regulation of KATP channel opening during ischemia remains poorly understood.
W. A. Coetzee, T. Y. Nakamura, J. F. Faivre   +2 more
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PIP2 and PIP as determinants for ATP inhibition of KATP channels.

, 1998
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP.
Tucker, Stephen, Oliver, D, Tucker, SJ, Krauter, T, Schulte, U, Fakler, B, Herlitze, S, Ruppersberg, JP, Baukrowitz, T   +8 more
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Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia

, 2010
The pancreatic β-cell ATP-sensitive K+ channel (KATP channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion.
Chela James, Khalid Hussain, Kate Bennett   +2 more
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The unusual stoichiometry of ADP activation of the KATP channel

, 2014
KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Vivaudou, Michel, Michel Vivaudou, Michel eVivaudou, Eric Hosy, Hosy, Eric, Eric eHosy   +5 more
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短暂缺氧对心肌细胞 KATP通道的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2000
【目的】探讨 KATP通道在心肌缺血预适应( IP)中的作用。【方法】用膜片钳单通道记录技术的细胞贴附式研究急 性短暂缺氧复氧对新鲜分离的豚鼠心肌细胞细胞膜 KATP通道影响 。【结果】短暂缺氧 10 min 可明显引起细胞膜 KATP通道的 开放,缺氧诱导的 KATP通道的开放以簇状开放为主。复氧 2 min及用 2 mmol/L ATP 可抑制通道开放,其电导值为 89.
冯　力, 刘　杰
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