Results 91 to 100 of about 19,437 (170)

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
core  

The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

Pharmacogenomics and Personalized Medicine, 2010
Veronica Lang, Peter E LightDepartment of Pharmacology and Alberta Diabetes Institute, Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Neonatal diabetes mellitus (NDM)
Veronica Lang, Peter E Light
doaj  

Metabolically-sensitive (KATP) channels in enteric neurons

, 2007
Metabolically-sensitive (KATP) channels in enteric ...
Hayato Matsuyama (19187950), Trung V Nguyen (19187959), Karina Needham (593727), Louise Pontell (19187956), John Furness (13070439), Billie Hunne (18608647), Kan Tan (2804611), Kulmira Nurgali (799081)   +7 more
core  

Closure by iptakalim, a cardiovascular KATP channel opener, of rat pancreatic β-cell KATP channels and its molecular basis [PDF]

application/pdfDiabetes mellitus is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both.
Wu, Jie, Wakui, Makoto, Misaki, Naoko, Suga, Sechiko, Lin, Yu-Fung, Mao, Xia   +5 more
core   +1 more source

Role of Cardiac KATP Channels During Anoxia and Ischemia

, 1997
In isolated heart cells, maintained anoxia causes a transient opening of KATP channels. In the ischemic myocardium, this extra K+ conductance results in a decreased contractility and may be arrhythmogenic.
K Benndorf, H Hirche, C Gebhardt, S Thierfelder, B Doepner   +4 more
core   +1 more source

Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater [PDF]

Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3 ...
Corradi, Jeremias, Satin, Leslie Sherwin, Sherman, Arthur Stewart   +2 more
core   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Phentolamine block of KATP channels is mediated by Kir6.2.

, 1997
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus ...
Proks, P, Ashcroft, FM, Ashcroft, Frances   +2 more
core   +1 more source

短暂缺氧对心肌细胞 KATP通道的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2000
【目的】探讨 KATP通道在心肌缺血预适应( IP)中的作用。【方法】用膜片钳单通道记录技术的细胞贴附式研究急 性短暂缺氧复氧对新鲜分离的豚鼠心肌细胞细胞膜 KATP通道影响 。【结果】短暂缺氧 10 min 可明显引起细胞膜 KATP通道的 开放,缺氧诱导的 KATP通道的开放以簇状开放为主。复氧 2 min及用 2 mmol/L ATP 可抑制通道开放,其电导值为 89.
冯　力, 刘　杰
doaj  

Sodium butyrate activates the KATP channels to regulate the mechanism of Parkinson's disease microglia model inflammation

Immunity, Inflammation and Disease
Background Parkinson's disease (PD) is a common neurodegenerative disorder. Microglia‐mediated neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. Activation of adenosine triphosphate (ATP)‐sensitive potassium
Ye Xu, Laofu Wen, Yunyi Tang, Zhenqiang Zhao, Miaojing Xu, Tan Wang, Zhibin Chen   +6 more
doaj   +1 more source