Results 91 to 100 of about 17,716 (217)

Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater [PDF]

Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3 ...
Corradi, Jeremias, Satin, Leslie Sherwin, Sherman, Arthur Stewart   +2 more
core   +1 more source

Activation of KATP channels in pain modulation: a systematic review of preclinical studies

Frontiers in Physiology
ObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +3 more
doaj   +1 more source

Role of Cardiac KATP Channels During Anoxia and Ischemia

, 1997
In isolated heart cells, maintained anoxia causes a transient opening of KATP channels. In the ischemic myocardium, this extra K+ conductance results in a decreased contractility and may be arrhythmogenic.
K Benndorf, H Hirche, C Gebhardt, S Thierfelder, B Doepner   +4 more
core   +1 more source

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels [PDF]

, 2013
Glucose-sensing (GS) behaviour in pancreatic ß-cells is dependent on ATP-sensitive K(+) channel (KATP) activity, which is controlled by the relative levels of the KATP ligands ATP and ADP, responsible for closing and opening KATP, respectively.
McCrimmon, Rory J.; id_orcid, Rory J. McCrimmon, Michael L. J. Ashford, Beall, Craig, Kenneth R. Watterson, Craig Beall, Watterson, Kenneth R., Craig Beall, McCrimmon, Rory J., Ashford, Michael L.J.; id_orcid, Ashford, Michael L.J.   +10 more
core   +1 more source

Dynamic duo: Kir6 and SUR in KATP channel structure and function

Channels
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel ...
Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng   +4 more
doaj   +1 more source

Metabolically-sensitive (KATP) channels in enteric neurons

, 2007
Metabolically-sensitive (KATP) channels in enteric ...
Hayato Matsuyama (19187950), Trung V Nguyen (19187959), Karina Needham (593727), Louise Pontell (19187956), John Furness (13070439), Billie Hunne (18608647), Kan Tan (2804611), Kulmira Nurgali (799081)   +7 more
core  

Phentolamine block of KATP channels is mediated by Kir6.2.

, 1997
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus ...
Proks, P, Ashcroft, FM, Ashcroft, Frances   +2 more
core   +1 more source

Myocardial Protection and the KATP Channel [PDF]

, 1995
1: The biology of KATP channels N.B. Standon. 2: Vascular pathology and the KATP channel U. Quast, S. Glocker. 3: Activation of the ATP-sensitive potassium channels: A novel pharmacological approach to myocardial protection? D.J. Hearse. 4: The relationship between the KATP channel and Myocardial preconditioning G.J. Gross, D.M. Yellon.
openaire   +1 more source

Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations

, 2010
Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Shield, JPH, Kapoor, RR, Hussain, K., Rubio-Cabezas, O., Kapoor, R. R., Banerjee, I, Sianhanidou, T, Siahanidou, T., Flanagan, SE, Akcay, T, Akcay, T., Cody, D., Siahanidou, T, Hussain, K, Ellard, S., Mali, G, Cody, D, Shield, JP, Shield, J. P. H., Rubio-Cabezas, O, Mali, G., Schwahn, B., Flanagan, S. E., Murphy, N, Murphy, N., Banerjee, I., Ellard, S, Schwahn, B   +27 more
core   +1 more source

Glucose Recruits KATP Channels via Non-Insulin-Containing Dense-Core Granules

, 2007
Summaryβ cells rely on adenosine triphosphate-sensitive potassium (KATP) channels to initiate and end glucose-stimulated insulin secretion through changes in membrane potential.
Juntti-Berggren, Lisa, Berggren, Per-Olof, Qiu, Hua, Köhler, Martin, Yang, Guang, Yang, Shao-Nian, Wenna, Nancy Dekki, Yu, Lina, Yu, Jia   +8 more
core   +1 more source