Results 71 to 80 of about 19,437 (170)

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

Cloning and functional expression of a rat heart KATP channel

, 1994
Potassium channels that are ATP-sensitive (KATP) couple membrane potential to the metabolic status of the cell. KATP channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates.
Ashford, M. L. J.; id_orcid, M. L. J. Ashford, C. T. Bond, J. P. Adelmair, Bond, C. T., T. A. Blair, Blair, T. A., Adelman, J. P.   +7 more
core   +1 more source

Intra‐Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia

Annals of the New York Academy of Sciences, Volume 1563, Issue 1, September 2026.
Glucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Samaneh Fatehi, Jonathan V. Rocheleau, Michael C. Riddell   +2 more
wiley   +1 more source

Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell KATP channels

Frontiers in Physiology
ATP-sensitive potassium (KATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion.
Natascia Vedovato, Natascia Vedovato, Frances M. Ashcroft, Brian Catchpole, Lucy J. Davison, Lucy J. Davison   +5 more
doaj   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

ATP-sensitive potassium channels gene polymorphism rs1799858 affects the risk of macro-/micro-vascular arteriosclerotic event in patients with increased low-density lipoprotein cholesterol levels

Lipids in Health and Disease, 2020
Background Plasma concentration of low-density lipoprotein cholesterol (LDL-C) is causally related to the risk of arteriosclerotic events. Whether ATP-sensitive potassium channels (KATP) genetic variants predict increased LDL-C concentration (≥1.8 mmol/L)
Cheng Liu, Tianwang Guan, Yanxian Lai, Jieming Zhu, Jian Kuang, Yan Shen   +5 more
doaj   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

Cardiovascular consequences of KATP overactivity in Cantu syndrome [PDF]

, 2018
Cantu syndrome (CS) is characterized by multiple vascular and cardiac abnormalities including vascular dilation and tortuosity, systemic hypotension, and cardiomegaly.
Kristina Hinman, G. Schuyler Brown, Huang, Yan, Hinman, Kristina, Colin G. Nichols, Mecham, Robert P, Sarah K. England, Harter, Theresa M, Maria S. Remedi, Matkovich, Scot J, Theresa M. Harter, Remedi, Maria S, Yan Huang, Nichols, Colin G, Haixia Zhang, Halabi, Carmen M, Kovacs, Attila, Scot J. Matkovich, Attila Kovacs, McClenaghan, Conor, Robert P. Mecham, England, Sarah K, Conor McClenaghan, Carmen M. Halabi, Zhang, Haixia, Brown, G Schuyler   +25 more
core   +1 more source

Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations [PDF]

, 2010
Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Shield, JPH, Kapoor, RR, Hussain, K., Rubio-Cabezas, O., Kapoor, R. R., Banerjee, I, Sianhanidou, T, Siahanidou, T., Flanagan, SE, Akcay, T, Akcay, T., Cody, D., Siahanidou, T, Hussain, K, Ellard, S., Mali, G, Cody, D, Shield, JP, Shield, J. P. H., Rubio-Cabezas, O, Mali, G., Schwahn, B., Flanagan, S. E., Murphy, N, Murphy, N., Banerjee, I., Ellard, S, Schwahn, B   +27 more
core   +1 more source