Results 81 to 90 of about 19,437 (170)

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Frontiers in Pharmacology, 2020
Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6.1 subunits, respectively, of KATP channels.
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico   +10 more
doaj   +1 more source

KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies

Frontiers in Neurology
Cumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as ...
Hassan Ali Suleiman Daoud, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +4 more
doaj   +1 more source

Glucose Recruits KATP Channels via Non-Insulin-Containing Dense-Core Granules [PDF]

, 2007
Summaryβ cells rely on adenosine triphosphate-sensitive potassium (KATP) channels to initiate and end glucose-stimulated insulin secretion through changes in membrane potential.
Juntti-Berggren, Lisa, Berggren, Per-Olof, Qiu, Hua, Köhler, Martin, Yang, Guang, Yang, Shao-Nian, Wenna, Nancy Dekki, Yu, Lina, Yu, Jia   +8 more
core   +1 more source

Activation of KATP channels in pain modulation: a systematic review of preclinical studies

Frontiers in Physiology
ObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +3 more
doaj   +1 more source

Novel Roles of Plasma Membrane KATP Channels in the Heart

, 2015
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. .
Youssef, Nermeen Hosny Ibrahim
core   +1 more source

Alterations in ventricular KATP channel properties during aging

, 2013
Coronary heart disease remains the principle cause of mortality in the United States. During aging, the efficiency of the cardiovascular system is decreased and the aged heart is less tolerant to ischemic injury.
Ramasamy, Ravichandran, Bao, Li, Taskin, Eylem, Ananthakrishnan, Radha, Schmidt, Ann M., Rosario, Rosa, Foster, Monique, Ray, Beevash, Howlett, Susan E., Coetzee, William A.   +9 more
core   +1 more source

Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

, 2010
Aim: This study was performed to assess the effect of selective sarcolemmal adenosine triphosphate (ATP)-sensitive K+ channel (KATP) inhibition and the mitochondrial KATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in ...
Ömer Bozdoğan, Ersöz Gonca
core   +1 more source

Dynamic duo: Kir6 and SUR in KATP channel structure and function

Channels
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel ...
Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng   +4 more
doaj   +1 more source

Nature's KATP-Channel Knockout

, 1997
We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy.
MJ Dunne, A Aynsley-Green, KJ Lindley
core   +1 more source

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +1 more source