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Cardiac KATP Channels in Health and Diseases
2013Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels were discovered in the heart almost 30 years ago. They are present in multiple tissues and link membrane excitability to the metabolic state of the cell. Under physiological conditions, cardiac KATP channels are predominantly closed, but they may open during exertion, stress, and ischemia ...
Hai Xia Zhang +2 more
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KATP channels as molecular sensors of cellular metabolism
Nature, 2006In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K(ATP)) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular ...
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KATP Channel-Independent Pathway and the Glucoreceptor
2018The biphasic response is a unique characteristic of glucose-stimulated insulin secretion by islet beta cells. Namely, upon exposure to a high concentration of glucose, insulin secretion increases sharply for approximately 5 min before it gradually wanes at the end of the first phase.
Toru Aizawa, Mitsuhisa Komatsu
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The role of KATP channels in cerebral ischemic stroke and diabetes
Acta Pharmacologica Sinica, 2018Hong-Shuo Sun +2 more
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