Results 171 to 180 of about 14,064 (215)

Pharmacological modulation of KATP channels

Biochemical Society Transactions, 2001
Pharmacological modulation of ATP-sensitive K+ (KATP) channels is used in the treatment of a number of clinical conditions, including type 2 diabetes and angina. The sulphonylureas and related drugs, which are used to treat type 2 diabetes, stimulate insulin secretion by closing KATP channels in pancreatic β-cells.
F. M. Gribble, F. Reimann
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Brain glucosensing and the KATP channel

Nature Neuroscience, 2001
An ATP-sensitive K+ channel in glucose-responsive neurons is shown to be required for the emergency response to severe glucose deprivation, but not necessarily for normal feeding.
Barry E. Levin, Ambrose A. Dunn-Meynell, Vanessa H. Routh   +2 more
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Nature's KATP-Channel Knockout

Physiology, 1997
We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy. We review how nature's KATP-channel knockout has important medical implications and how key lessons in physiology can be learned from studies of rare diseases.
MJ Dunne, A Aynsley-Green, KJ Lindley
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Neuroprotection by K channels

Journal of Molecular and Cellular Cardiology, 2005
The substantia nigra pars reticulata, the area with the highest expression of ATP-sensitive potassium channels in the brain, plays a pivotal role in suppressing the propagation of generalized seizures by its silence. Mice lacking the Kir6.2 subunit of the channels were extremely susceptible to generalized seizures after brief hypoxia. The nigral neuron
Katsuya, Yamada, Nobuya, Inagaki
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Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial KATP Channels, Blocks Sarcolemmal KATP Channels, and Confers Cardioprotection

The Journal of Pharmacology and Experimental Therapeutics, 2006
Bepridil, which is clinically useful in the treatment of arrhythmias, has been reported to inhibit sarcolemmal ATP-sensitive K(+) (sarcK(ATP)) channels. However, the effect of bepridil on mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels remains unclear.
Toshiaki, Sato, Alexandre D T, Costa, Tomoaki, Saito, Takehiko, Ogura, Hideyuki, Ishida, Keith D, Garlid, Haruaki, Nakaya   +6 more
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Clinical Exploitation of the KATP Channel

1995
Potassium ion (K+) channels play a dominant role in controlling the resting membrane potential of excitable cells. They are ubiquitous, structurally diverse and functionally are perhaps most usefully classified by what causes them to open or close.
Henry Purcell, Kim Fox
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The Biology of KATP Channels

1995
ATP-sensitive potassium channels (KATP channels) provide a mechanism for linking membrane potassium permeability to cellular metabolism. They have important functions in the tissues of central importance to this book, cardiac muscle and systemic and coronary vascular smooth muscle.
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Vascular Pathology and The KATP Channel

1995
K+ channels determine the resting membrane potential and cellular excitability of most cells [1], The opening of K+ channels shifts the membrane potential towards the K+ equilibrium potential which is around -90 mV. In excitable cells endowed with depolarization-activated Ca2+ channels (voltage-gated Ca2+ channels, VOCCs), hyperpolarization will ...
Ulrich Quast, Stefan Glocker
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KATP channels and basal coronary vascular tone

Cardiovascular Research, 1994
After reviewing recent experimental work from various laboratories we have come to the following conclusions. (1) An increase in transmural pressure causes depolarisation of coronary arterioles, which increases smooth muscle tone. Under these conditions the opening of KATP channels can induce a much larger change in membrane potential than in relaxed ...
J, Daut, H G, Klieber, S, Cyrys, T, Noack   +3 more
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Imaging and Quantification of Recycled KATP Channels

2013
This chapter describes immunochemistry-based methods to investigate recycling of membrane proteins at the cell surface. Two methods are described, one qualitative and the other quantitative. Both methods consist of two rounds of extracellular antibody capture.
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