Results 1 to 10 of about 56,140 (348)
KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer [PDF]
Frontiers in OncologyThe KEAP1/NRF2 pathway, a major regulator of the cellular oxidative stress response, is frequently activated in human cancers. Often mediated by loss-of-function mutations in KEAP1, this activation causes increased NRF2 transcriptional activity and ...
Nicholas E. Bambach +8 more
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Aquaculture Reports, 2020 Keap1 is an important component of Nrf2-Keap1 signaling pathways. However, information about Keap1 in T. ovatus is quiet limit. Thus, the full length of Keap1 was cloned from T. ovatus in this study.
Jiajun Xie, Xu Chen, Xuanshu He, Jin Niu
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Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak +3 more
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Frontiers in Pharmacology, 2022 Chronic obstructive pulmonary disease (COPD) is a severely disabling chronic lung disease characterized by persistent airway inflammation, which leads to limited expiratory airflow that deteriorates over time.
Yifan Xu +10 more
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OncoImmunology, 2021 Somatic mutations of STK11 or KEAP1 are associated with poor clinical outcomes for advanced non-small-cell lung cancer (aNSCLC) patients receiving immune checkpoint inhibitors (ICIs), chemotherapy, or targeted therapy.
Wei Nie +19 more
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Roles of autophagy and p62 /SQSTM1 in hepatic ischemia-reperfusion
生物医学转化, 2021 Autophagy is a lysosomal dependent degradation system, and p62 itself is an importantprotein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 playsan important role in selective autophagy such as mitochondrial
Zhang Haiming, Zhu Zhijun
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Journal of Experimental Life Science, 2020 Aging is caused by an imbalance between antioxidants and ROS. Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant genes. Under normal conditions, Nrf2 will bind keap1 and cause degradation of Nrf2. Nrf2
Viona Faiqoh Hikmawati +3 more
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Antioxidants, 2022 NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for ...
Eun Young Kim, Jae Man Lee
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KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]
Open Biology, 2020 Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu +1 more
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Computational study of Curcuma zanthorrhiza Roxb compounds as potential antidiabetic towards alpha-amylase, alpha-glucosidase, and Keap1 inhibition [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Curcuma zanthorrhiza Roxb is traditionally used as a medicinal herb that is believed might cure some diseases. However, there is still a lack of information about the underlying mechanism of bioactive compounds from C.
Sasangka Prasetyawan +2 more
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