Results 91 to 100 of about 56,140 (348)

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Effect of Low-Level Laser Therapy on the Nrf2/Keap1 Pathway in NMRI Mice with Testicular Torsion [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Testicular torsion (TT) is a urological emergency characterized by twisting of the spermatic cord, which reduces blood flow and leads to testicular ischemia.
Mohammad Bayat, Mahsa Soltani, Roohollah Torabi, maryam baazm, Mitra Barzroodi   +4 more
doaj  

Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway

Pharmaceutical Biology, 2019
Context: Bajijiasu (BJJS), a main bioactive compound from Morinda officinalis F.C. How. (Rubiaceae), is widely administered concomitantly with other drugs for treating male impotence, female infertility, fatigue, chronic rheumatism, depression, etc ...
Xin Yang, Guoyan Hu, Lijuan Lv, Ting Liu, Longkai Qi, Guozhan Huang, Dongqing You, Jun Zhao   +7 more
doaj   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (γ-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Antonicelli, Aoki, Arfsten, Aruoma, Asti, Ault, Azzi, Bakin, Banhegyi, Banhegyi, Beck, Beeh, Beeh, Bindoli, Biswas, Borgstrom, Braga, Bridgeman, Bunnell, Burgunder, Butterworth, Cantin, Chakravarthi, Chan, Chan, Chen, Chen, Chuang, Church, Colombo, Cotgreave, Cotgreave, Crouch, Crystal, Das, De Benedetto, de Boer, De Caro, Decramer, Decramer, Dekhuijzen, Deleve, Dickinson, Dinkova-Kostova, Drost, Dueholm, Ekberg-Jansson, Erickson, Forman, Galloway, Gerrits, Gillissen, Grandjean, Grigg, Guidot, Haddad, Halliwell, Harju, Harper, Hayes, He, Holdiness, Huang, Hwang, Inci, Irfan Rahman, Ishibashi, Itoh, Janssen, Jardine, Jessop, Jeyapaul, Kang, Kasielski, Katayama, Kidd, Kim, Kinnula, Kinnula, Kinnula, Kinnula, Kobayashi, Kode, Koike, Komatsu, Krzywanski, Kwong, Lee, Lee, Lee, Leonard, Liu, Liu, Lomaestro, Lowry, Lu, Luppi, Mattes, McKone, Meister, Meyer, Miao, Monova, Moran, Moretti, Moretti, Mulcahy, Nakayama, Pacht, Paget, Park, Parmentier, Peltoniemi, Pietarinen-Runtti, Pinkus, Poole, Poole, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rasmusse, Reddy, Reynaert, Rhee, Roum, Rutkowski, Sadowska, Saibal K. Biswas, Shi, Shin, Siedlinski, Singh, Smith, Stey, Suter, Tanaka, Tian, Tirouvanziam, Tomonari, Trachootham, Tsikas, Tu, Usatyuk, Valko, van der Toorn, Van Schooten, Wakabayashi, Wang, White, Wild, Wood, Wood, Yang, Yang, Yang, Yeh, Zhang, Zhang   +162 more
core   +1 more source

Effect of Resistance and Endurance Trainings on Nrf2/Keap1 Signaling Pathway in Testicular Tissue of Type 2 Diabetic Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: The antioxidant Nrf2/Keap1 pathway prevents cellular damages against oxidative stress and this pathway is disrupted following diabetes.
Zahra Nadi, Yusef Abbasi, Farideh Jalali Mashayekhi, Mohammad Bayat, Parvindokht Bayat, Maryam Baazm   +5 more
doaj  

Wearable Thermoelectric Generators for In Vivo Modulation of Insulin Release

Advanced Energy Materials, EarlyView.
This work presents a wearable, self‐powered thermoelectric system (IGNITE) that sustainably harvests body heat to electrically stimulate engineered human cells for insulin release. Operating autonomously without batteries, IGNITE achieves glycemic control in diabetic mice, demonstrating a significant advance in bioelectronic medicine and setting the ...
Debasis Maity, Jinbo Huang, Martin Fussenegger   +2 more
wiley   +1 more source

Targeting crosstalk between Nrf-2, NF-κB and androgen receptor signaling in prostate cancer [PDF]

, 2018
Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa).
Khurana, Namrata, Sikka, Suresh C
core   +2 more sources

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

Oncotarget, 2017
The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through the induction of several antioxidant defence genes implicated in chemotherapeutic drugs resistance of tumor cells. An increasing body of evidence supports a key role for Keap1/Nrf2 pathway in kidney diseases and renal cell carcinoma (RCC), but data concerning the molecular
Fabrizio FP, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, Poeta L, Gallucci M, Sentinelli S, Graziano P, Parente P, Pompeo V, De Salvo L, Simone G, Papalia R, Picardo F, Balsamo T, Flammia GP, Trombetta D, Pantalone A, Kok K, Paranita F, Muscarella LA, Fazio VM   +23 more
openaire   +6 more sources

RPSLearner: A Novel Approach Based on Random Projection and Deep Stacking Learning for Categorizing Non‐Small Cell Lung Cancer

Advanced Intelligent Systems, EarlyView.
Identifying non‐small cell lung cancer (NSCLC) subtypes is essential for precision cancer treatment. Conventional methods are laborious, or time‐consuming. To address these concerns, RPSLearner is proposed, which combines random projection and stacking ensemble learning for accurate NSCLC subtyping. RPSLearner outperforms state‐of‐the‐art approaches in
Xinchao Wu, Jieqiong Wang, Shibiao Wan
wiley   +1 more source