Results 11 to 20 of about 56,140 (348)

Molecular Evolution of Keap1 [PDF]

Journal of Biological Chemistry, 2008
Keap1 is a BTB-Kelch-type substrate adaptor protein of the Cul3-dependent ubiquitin ligase complex. Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the inducible expression of many cytoprotective genes.
Li Li, Makoto Kobayashi, Hiroshi Kaneko, Yaeko Nakajima-Takagi, Yuko Nakayama, Masayuki Yamamoto   +5 more
openaire   +3 more sources

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation [PDF]

Cell Communication and Signaling, 2020
Background and purpose Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal.
Meiling Gong, Yan Li, Xiaoping Ye, Linlin Zhang, Zhifang Wang, Xiaowen Xu, Yejing Shen, Cuixia Zheng   +7 more
doaj   +3 more sources

Keap1/Nrf2 Signaling Pathway [PDF]

Antioxidants, 2021
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
openaire   +4 more sources

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]

, 2020
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A., DeNicola, Gina M., Elkins, Cody M., Falzone, Aimee, Haura, Eric B., Prieto-Farigua, Nicolas, Torrente, Laura   +6 more
core   +1 more source

Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention [PDF]

, 2014
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1-5 µM) to promote cell proliferation to 120-143% of the controls in a number of human cell lines, whilst at high levels (10-40 µM) it inhibited such cell proliferation.
A Arlt, A Giudice, A Herman-Antosiewicz, A Lau, A Lister, A Melchini, A Speciale, AA Alfadda, AJ Vargas, AT Dinkova-Kostova, AV Gasper, C Cornelius, C Fimognari, C Fimognari, Changhao Sun, CR Zhao, D Li, D Rand, D Ren, Daotai Nie, DD Zhang, DS Michaud, E Warwick, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, ER Hahm, F Ekiz, F Galgano, F Zanichelli, GM DeNicola, GR Fenwick, GS Omenn, HK Na, I Misiewicz, I Oehme, IS Santos, J Jakubikova, J Watson, JD Clarke, JD Hayes, JD Watson, JM Cramer, K Pietsch, K Suppipat, KA Moy, KL Cheung, L Gamet-Payrastre, L Kuang, L Ye, LN Barrera, LS Cooley, M McMahon, MB Sporn, MP Mattson, MP Mattson, P Sestili, P Shelton, PE Miller, R Brigelius-Flohe, RF Clayton, RK Thimmulappa, S Homma, SA McNaughton, SJ Jackson, SL Navarro, T Hara, T Nishikawa, T Xu, TG Son, TW Kensler, TW Kensler, V Calabrese, V Rungapamestry, W Hendrickx, Wei Wang, X Ma, X Yu, XJ Wang, Y Ji, Y Li, Y Mitsuishi, Y Shan, Y Zhang, Y Zhang, Y Zhang, Y Zhang, YJ Surh, Yongping Bao, YS Keum, Zhigang Zhou   +91 more
core   +18 more sources

miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

Open Medicine, 2023
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by ...
Zhao Jingyun, Liu Leilei, Zhao Wei, Lv Cuiting, Zhang Na, Jia Xinzhuan, Zhang Zhengmao   +6 more
doaj   +1 more source

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

Keap1 inhibition attenuates glomerulosclerosis [PDF]

Nephrology Dialysis Transplantation, 2014
NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has
Yoichi, Miyazaki, Akihiro, Shimizu, Ira, Pastan, Keiko, Taguchi, Eriko, Naganuma, Takafumi, Suzuki, Tatsuo, Hosoya, Takashi, Yokoo, Akihiko, Saito, Toshio, Miyata, Masayuki, Yamamoto, Taiji, Matsusaka   +11 more
openaire   +2 more sources

Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1

The Journal of Toxicological Sciences, 2023
Tributyltin (TBT) is an environmental chemical, which was used as an antifouling agent for ships. Although its use has been banned, it is still persistently present in ocean sediments. Although TBT reportedly causes various toxicity in mammals, few studies on the mechanisms of biological response against TBT toxicity exist.
Misaki, Hatano, Shunichi, Hatamiya, Masatsugu, Miyara, Yaichiro, Kotake   +3 more
openaire   +2 more sources

Keap1–Nrf2 signalling in pancreatic cancer [PDF]

The International Journal of Biochemistry & Cell Biology, 2015
Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes.
Hayes, Alastair J, Skouras, Christos, Haugk, Beate, Charnley, Richard M   +3 more
openaire   +3 more sources