Results 221 to 230 of about 56,140 (348)

Cuspidatyl Ferulate, a Novel Phenolic Acid from <i>Hyssopus cuspidatus</i> Borris, Protects Hepatocytes Against Oxidative Damage via Keap1 Interaction. [PDF]

Antioxidants (Basel)
Liu X, Zhang Z, Gao D, Yang X, Liu L, Wang G, Song Z, Fang W, Wang S.   +8 more
europepmc   +1 more source

Fermented Cornus officinalis Fruit Protects Against Alcohol-Induced Liver Injury via Regulating Keap1–Nrf2–HO-1/GPX4 Pathway: UPLC-MS/MS Characterization, Network Pharmacology, and Animal Validation

Xian Tao, H. L. Li, Jie Zeng, Mei Fang Peng, Qing Liu, Lan Luo, Yan Wang, Juan Yang, X L Yang, Liangqun LI   +9 more
openalex   +1 more source

TARGETING THE NRF2/KEAP1 INTERACTION

, 2014
The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic diseases.
openaire   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

SMP30 May protect human lens epithelial cells against high glucose-induced oxidative damage by regulating the Keap1/Nrf2/NQO1 pathway. [PDF]

Sci Rep
Yang Y, Chai H, Lan T, Gan Q, Liang Y, Tang C, Zeng Y, Liang H.   +7 more
europepmc   +1 more source

Supplementary Figure Legends 1-5 from NRF2-Driven <i>KEAP1</i> Transcription in Human Lung Cancer

, 2023
Yijun Tian, Qian Liu, Shengnan Yu, Qian Chu, Yuan Chen, Kongming Wu, Liang Wang   +6 more
openalex   +1 more source

Lactobacillus helveticus ZJUIDS12 Rescues Alcohol‐Associated Liver Disease via a Clostridium butyricum‐Regulated Intestinal Reg3γ Pathway

Food Frontiers, Volume 7, Issue 1, January 2026.
Lactobacillus helveticus ZJUIDS12 rescues alcohol‐associated liver disease via a Clostridium butyricum‐regulated intestinal Reg3γ pathway. ABSTRACT Alcohol‐associated liver disease (ALD) has become a serious public health issue worldwide. This study was conducted to investigate the protective role of Lactobacillus helveticus ZJUIDS12 (Z12) on ALD. Z12 (
Qinchao Ding, Feiwei Cao, Shanglei Lai, Jundi Yu, Yibo Zeng, Teresa G. Valencak, Shuo Zhang, Xiu Zhang, Xiaobing Dou, Songtao Li, Daxi Ren   +10 more
wiley   +1 more source

Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy. [PDF]

J Enzyme Inhib Med Chem
Gao S, Shi X, Yang S, Wang Y, Wang Q, Yang M.   +5 more
europepmc   +1 more source

Postbiotics in Functional Foods: Microbial Derivatives Shaping Health, Immunity and Next‐Generation Nutrition

Food Frontiers, Volume 7, Issue 1, January 2026.
Postbiotics are bioactive compounds derived from microbial fermentation, including short‐chain fatty acids, extracellular polysaccharides, and cell wall components. These molecules support health by regulating immune responses, enhancing gut barrier integrity, reducing inflammation, and modulating gut–brain and gut–liver communication.
Alice Njolke Mafe, Javad Sharifi‐Rad, Daniela Calina, Ayobami Joshua Ogunyemi, Abiola O. Tubi   +4 more
wiley   +1 more source

Druggable genome CRISPR screening identifies the KEAP1/NRF2 axis as a mediator of PD-L1 expression. [PDF]

Commun Biol
Seker-Polat F, Rogozinska M, Ban Y, Abdula F, Buyukcelebi K, Xie P, Fan J, Abbaszadeh N, Kingham Y, Paylakhi SZ, Zhang B, Adli M.   +11 more
europepmc   +1 more source