Results 41 to 50 of about 56,140 (348)

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources

Characterizing genomic alterations in cancer by complementary functional associations. [PDF]

, 2016
Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain ...
A Azzalini, A Kraskov, A Kraskov, A Singh, A Young, AA Margolin, AJ Butte, Amir Reza Alizad-Rahvar, Andrew Aguirre, Arthur Liberzon, Aviad Tsherniak, B Luo, Barbara A Weir, C Ding, C Scholl, CA Miller, CD Correa, Chet Birger, Chiara Romualdi, CJ Vaske, Cory M Johannessen, D Feng, D Guardavaccaro, D Malhotra, D Nijhawan, D Pandey, DA Barbie, Daniel DiCara, David A Barbie, David J Konieczkowski, DD Shao, Diane D Shao, DP Hollern, DP Minde, DV Foster, EH Linfoot, Eliezer M Van Allen, F Vandin, F Vandin, Francisca Vazquez, G Ciriello, GA Darbellay, Gabriela Alexe, Gabriele Sales, Gad Getz, GM DeNicola, H Joe, H Peng, H Zou, Heidi Greulich, HW Cheung, J Barretina, J Lin, J Rosenbluh, JA McCubrey, Jesse S Boehm, Jill P Mesirov, JN Weinstein, Jong Wook Kim, Joseph Rosenbluh, JP Brunet, JS Boehm, L Chin, L Chin, L Waldron, Levi A Garraway, LM Solis, M Meyerson, Mahmoud Ghandi, Masoud Ardakani, MB Raeder, MD Leiserson, ME Abazeed, Michael Noble, Mohamed E Abazeed, MS Lawrence, MS Lawrence, Olga B Botvinnik, Omar Abudayyeh, P Tamayo, Pablo Tamayo, Peter S Hammerman, R Beroukhim, R Firestein, R Steuer, Rameen Beroukhim, S Pendyala, S Sheather, SS Brar, T Valenta, Travis I Zack, William C Hahn, Y Gu, Yashaswi Shrestha   +93 more
core   +1 more source

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

Molecules, 2020
The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li, Yueli Chen, Danyang Jiao, Shuhua Yang, Lin Li, Peng Li   +5 more
doaj   +1 more source

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
doaj   +1 more source

Structural Characterization of KEAP1 R415K to Guide the Design of KEAP1‐Nrf2 Peptide Inhibitors

The FASEB Journal, 2021
Oxidative stress can cause extensive damage to DNA, proteins, and lipids. Thus, long‐term oxidative stress has been linked to many diseases including cancer and Alzheimer's disease. The highly‐charged binding interface between regulatory protein Kelch‐like ECH‐associated protein 1 (KEAP1) and transcription factor nuclear erythroid factor 2‐like 2 (Nrf2)
Gwendolyn Pyeatt, Samantha Muellers, Adrian Whitty, Karen Allen   +3 more
openaire   +1 more source

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines

Ecotoxicology and Environmental Safety
Acute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure.
Mengdi Zhang, Jindong Gao, Md. F. Kulyar, Wanhe Luo, Guodong Zhang, Xiaoqi Yang, Tianguang Zhang, Haihang Gao, Yuxuan Peng, Jiabin Zhang, Muhammad Altaf, Samah Attia Algharib, Donghai Zhou, Jianzhong He   +13 more
doaj   +1 more source

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

Antioxidants, 2022
KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero, Guadalupe Martinez-Chacón, Sokhna M. S. Yakhine-Diop, Gema Duque-González, Mario Rodríguez-Arribas, Eva Alegre-Cortés, Marta Paredes-Barquero, Saray Canales-Cortés, Elisa Pizarro-Estrella, Antonio Cuadrado, Rosa Ana González-Polo, José M. Fuentes, Mireia Niso-Santano   +12 more
doaj   +1 more source

NQO1 Enzyme and its Role in Cellular Protection; an Insight

Iberoamerican Journal of Medicine, 2020
NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing
Ahmed Atia, Azman Abdullah
doaj   +1 more source

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals [PDF]

Antioxidants, 2020
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid 2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine Nrf2/Keap1) signaling. Unlike the genetic changes affecting DNA sequence, the reversible nature of epigenetic alterations provides an attractive avenue for cancer interception ...
Shamee Bhattacharjee, Roderick H. Dashwood   +1 more
openaire   +3 more sources