Results 181 to 190 of about 6,637 (212)
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Detection of keratan sulfate by immunological methods in commercial chondroitin sulfate preparations
Carbohydrate Polymers, 2014Chondroitin sulfate (CS), a well known nutraceutical, and keratan sulfate (KS) are glycosaminoglycans involved in the structure of cartilage proteoglycan, aggrecan. Since CS is extracted from cartilage, there may be a possibility that purified CS is contaminated with small amount of KS.
T Nakano, Lech Ozimek
exaly +3 more sources
Biosynthesis of Keratan Sulfate
2009Keratan sulfate (KS) is a poly-sulfated glycosaminoglycan with a poly-N-acetyllactosamine linear chain structure. KS is a rich component in cornea, and is also present in cartilage and brain. In cornea, KS plays important roles in maintaining water content and developing collagen matrix. Recent studies have demonstrated its association with Alzheimer’s
Akira Seko, Katsuko Yamashita
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Keratan sulfate exacerbates experimental autoimmune encephalomyelitis
Journal of Neuroscience Research, 2015Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis ...
Rino, Ueno +5 more
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Identification and quantitation of keratan sulfate in urine
Clinica Chimica Acta, 1974Abstract The purpose of the present artical is to indicate reliable and specific methods for identification and quantitation of keratan sulfate in urine. Thinlayer chromatography on silica gel or cellulose allows rapid and specific characterization, whereas prior isolation on Dowex 1×2 with selective elution with 3.0 M NaCl only allows quantitative ...
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Vacuum ultraviolet circular dichroism of keratan sulfate
Biochimica et Biophysica Acta (BBA) - General Subjects, 1987The vacuum ultraviolet CD of keratan sulfate reveals an intense negative CD band at 171 nm. Its intensity can be rationalized with a recently proposed quadrant rule in terms of the acetamido group being slightly tilted toward the hexosaminidic linkage oxygen.
E S, Stevens, B, Lin
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Mannose in the Keratan Sulfate from Bovine Cornea
The Journal of Biochemistry, 1982After exhaustive digestion of bovine corneas with a protease, keratan sulfate fractions of different chain length were obtained by ethanol fractionation on a cellulose column, followed by ion-exchange column chromatography. Compositional analysis of these fractions showed that aspartic acid is the predominant amino acid and that the keratan sulfate in ...
H, Yamaguchi, T, Nakai
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Brain Keratan Sulfate and Glial Scar Formation
Annals of the New York Academy of Sciences, 2006Abstract: In response to injury to the central nervous system (CNS), reactive astrocytes appear and accumulate in the wounded area, leading to glial scar formation. Glial scar is the physical barrier to axonal regeneration of injured neurons. Chondroitin sulfate proteoglycans are inhibitory to axon outgrowth and are upregulated in reactive astrocytes
Haoqian, Zhang +2 more
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Serum keratan sulfate levels in osteoarthritis patients
Arthritis & Rheumatism, 1988AbstractSerum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more
M B, Sweet +7 more
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Impaired degradation of keratan sulfate in GM1-gangliosidosis
Clinica Chimica Acta, 1982Abstract We have prepared a new radiolabeled substrate (galactose-N-acetylglucosamine 6-sulfate-[1-3H]galactitol), from shark cartilage keratan sulfate, for an assay of acid β-galactosidase activity. Using this substrate, we found that there was a striking deficiency of β-galactosidase activity in the cultured skin fibroblasts of patients with GM1 ...
T, Yutaka +3 more
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Keratan Sulfate: Biosynthesis, Structures, and Biological Functions
2014Keratan sulfate is a glycosaminoglycan that has been investigated in the cornea and skeletal tissues for decades. Endoglycosidases and monoclonal antibodies specific for keratan sulfate have been developed. These materials have facilitated the analysis of keratan sulfate biosynthesis and structures. Likewise, they have expedited study of the biological
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