Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +2 more sources
The role of aggrecan in normal and osteoarthritic cartilage [PDF]
Journal of Experimental Orthopaedics, 2014 Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj +2 more sources
Keratan Sulfate Biosynthesis [PDF]
IUBMB Life, 2002 AbstractKeratan sulfate was originally identified as the major glycosaminoglycan of cornea but is now known to modify at least a dozen different proteins in a wide variety of tissues. Despite a large body of research documenting keratan sulfate structure, and an increasing interest in the biological functions of keratan sulfate, until recently little ...
James L. Funderburgh
openalex +5 more sources
Increased Urinary Excretion of Keratan Sulfate in Fucosidosis [PDF]
Clinical Chemistry and Laboratory Medicine, 1978 In two children exhibiting the clinical symptoms of fucosidosis, the diagnosis was biochemically ascertained by the demonstration of a profound altpha-L-fucosidase deficiency in cultured skin fibroblasts. The non-dialysed urines of these fucosidosis patients were separated into two fractions by chromatography on Biogel P-2.
H. Greiling +3 more
openalex +4 more sources
Distribution of keratan sulfate in cartilage proteoglycans.
Journal of Biological Chemistry, 1977 After chondroitinase digestion of bovine nasal and tracheal cartilage proteoglycans, subsequent treatment with trypsin or trypsin followed by chymotrypsin yielded two major types of polypeptide-glycosaminoglycan fragments which could be separated by Sepharose 6B chromatography.
Dick Heinegård, Inge Axelsson
openalex +4 more sources
Characterization and Determination of Human Urinary Keratan Sulfate.
Chemical and Pharmaceutical Bulletin, 1998 Keratan sulfate was isolated from normal human urine and was characterized by sugar compositional analysis and H-NMR spectroscopy. It was found that KS from human urine is classified as skeletal type (KS-II type chain) with an O-glycosidic linkage between galactosamine and serine (or threonine).
Hidenao Toyoda +5 more
openalex +5 more sources
Persistent elevations of alkaline phosphatase as an early indicator of GM1 gangliosidosis [PDF]
Molecular Genetics and Metabolism ReportsGLB1-related disorders are autosomal recessive lysosomal diseases caused by enzymatic deficiency of β-galactosidase. Enzymatic deficiency of β-galactosidase may lead to one of two phenotypes, GM1 gangliosidosis or mucopolysaccharidosis IVB (MPS IVB). GM1
Iskren Menkovic +6 more
doaj +2 more sources
Residual keratan sulfate in chondroitin sulfate formulations for oral administration
Carbohydrate Polymers, 2012 Chondroitin sulfate is a biomedical glycosaminoglycan (GAG) mostly used as a dietary supplement. We undertook analysis on some formulations of chondroitin sulfates available for oral administration. The analysis was based on agarose-gel electrophoresis, strong anion-exchange chromatography, digestibility with specific GAG lyases, uronic acid content ...
Vitor H. Pomin +3 more
openalex +4 more sources
Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea. [PDF]
Invest Ophthalmol Vis Sci, 2018 Purpose: Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine–transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7).
Littlechild SL +7 more
europepmc +4 more sources
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs. [PDF]
JIMD Rep, 2017 Ellsworth KA +3 more
europepmc +3 more sources