Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +2 more sources
Keratan sulfate (KS)âproteoglycans and neuronal regulation in health and disease: the importance of KSâglycodynamics and interactive capability with neuroregulatory ligands [PDF]
Journal of Neurochemistry, 2019 Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties.
J. Melrose
semanticscholar +2 more sources
A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns. [PDF]
J Am Chem SocKeratan sulfate (KS) is a proteoglycan that is widely expressed in the extracellular matrix of various tissue types, where it performs multiple biological functions.
Wu Y +6 more
europepmc +2 more sources
Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides. [PDF]
Sci Rep, 2020 Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular dynamics (MD) simulations to characterize interactions of corneal keratan ...
Miller MC +7 more
europepmc +2 more sources
Role of keratan sulfate expression in human pancreatic cancer malignancy. [PDF]
Sci Rep, 2019 Keratan sulfate (KS) is a sulfated linear polymer of N-acetyllactosamine. Proteoglycans carrying keratan sulfate epitopes were majorly observed in cornea, cartilage and brain; and mainly involved in embryonic development, cornea transparency, and wound ...
Leiphrakpam PD +7 more
europepmc +2 more sources
GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain. [PDF]
Sci Rep, 2019 Keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N-acetylglucosamine (GlcNAc) and galactose. We have previously shown that GlcNAc-6-O-sulfotransferase
Narentuya +9 more
europepmc +2 more sources
Keratan Sulfate Biosynthesis [PDF]
IUBMB Life, 2002 AbstractKeratan sulfate was originally identified as the major glycosaminoglycan of cornea but is now known to modify at least a dozen different proteins in a wide variety of tissues. Despite a large body of research documenting keratan sulfate structure, and an increasing interest in the biological functions of keratan sulfate, until recently little ...
James L Funderburgh
exaly +3 more sources
Isolation of Keratan Sulfate Disaccharide-branched Chondroitin Sulfate E from Mactra chinensis [PDF]
Bio-Protocol, 2017 Glycosaminoglycans (GAGs) including chondroitin sulfate (CS), dermatan sulfate (DS), heparin (HP), heparan sulfate (HS) and keratan sulfate (KS) are linear, sulfated repeating disaccharide sequences containing hexosamine and uronic acid (or galactose in ...
Kyohei Higashi, Toshihiko Toida
doaj +2 more sources
Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways. [PDF]
Glycobiology, 2018 Human siglecs are a family of 14 sialic acid-binding proteins, most of which are expressed on subsets of immune cells where they regulate immune responses.
Gonzalez-Gil A +11 more
europepmc +2 more sources
The role of aggrecan in normal and osteoarthritic cartilage [PDF]
Journal of Experimental Orthopaedics, 2014 Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj +2 more sources