Identification of an Immunoglobulin Paratope Binding to Keratan Sulfate and Expression of a Single-Chain Derivative for Imaging [PDF]
BiomoleculesKeratan sulfate (KS) is a negatively charged carbohydrate linked to proteins. Several KS-bearing structural glycosaminoglycans participate to maintain the homeostasis of a functional extracellular matrix.
Burak Boyraz +2 more
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Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain [PDF]
Frontiers in Neuroanatomy, 2022 Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura +6 more
doaj +2 more sources
Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan [PDF]
Biology, 2020 The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering +3 more
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Isolation of Keratan Sulfate Disaccharide-branched Chondroitin Sulfate E from Mactra chinensis [PDF]
Bio-Protocol, 2017 Glycosaminoglycans (GAGs) including chondroitin sulfate (CS), dermatan sulfate (DS), heparin (HP), heparan sulfate (HS) and keratan sulfate (KS) are linear, sulfated repeating disaccharide sequences containing hexosamine and uronic acid (or galactose in ...
Kyohei Higashi, Toshihiko Toida
doaj +2 more sources
GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium [PDF]
MoleculesWe recently showed that 6-sulfo sialyl N-acetyllactosamine (LacNAc) in O-linked glycans recognized by the CL40 antibody is abundant in the pleural mesothelium under physiological conditions and that these glycans undergo complementary synthesis by ...
Yoshiko Takeda-Uchimura +6 more
doaj +2 more sources
Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. [PDF]
PLoS ONE, 2020 Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete.
Julie A D Van +10 more
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Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. [PDF]
PLoS ONE, 2013 Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano +15 more
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Keratan sulfate phenotype in the β-1,3-N-acetylglucosaminyltransferase-7-null mouse cornea [PDF]
Invest Ophthalmol Vis Sci, 2018 Purpose: Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine–transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7).
Akama, T.O. +7 more
core +3 more sources
Exploiting Substrate Specificities of 6‑O‑Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides [PDF]
JACS Au, 2023 Yunfei Wu +7 more
doaj +2 more sources
Immunolocalization of keratan sulfate in rat spinal tissues using the keratanase generated BKS-1(+) neoepitope: correlation of expression patterns with the slass II SLRPs, lumican and keratocan [PDF]
Cells, 2020 This study has identified keratan sulfate in fetal and adult rat spinal cord and vertebral connective tissues using the antibody BKS-1(+) which recognizes a reducing terminal N-acetyl glucosamine-6-sulfate neo-epitope exposed by keratanase-I digestion ...
Hayes, Anthony J., Melrose, James
core +3 more sources