Results 41 to 50 of about 10,759 (233)

Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans, Van Renne, Nicolaas, Wei, Ruifang   +2 more
core   +1 more source

Collagens and proteoglycans of the corneal extracellular matrix

Brazilian Journal of Medical and Biological Research, 2003
The cornea is a curved and transparent structure that provides the initial focusing of a light image into the eye. It consists of a central stroma that constitutes 90% of the corneal depth, covered anteriorly with epithelium and posteriorly with ...
Y.M. Michelacci
doaj   +1 more source

Recommendations for the management of MPS IVA: systematic evidence- and consensus-based guidance. [PDF]

, 2019
IntroductionMucopolysaccharidosis (MPS) IVA or Morquio A syndrome is an autosomal recessive lysosomal storage disorder (LSD) caused by deficiency of the N-acetylgalactosamine-6-sulfatase (GALNS) enzyme, which impairs lysosomal degradation of keratan ...
Akyol, Mehmet Umut, Alden, Tord D, Amartino, Hernan, Ashworth, Jane, Belani, Kumar, Berger, Kenneth I, Borgo, Andrea, Braunlin, Elizabeth, Eto, Yoshikatsu, Giugliani, Roberto, Gold, Jeffrey I, Harmatz, Paul, Hendriksz, Christian, Jester, Andrea, Jones, Simon A, Karsli, Cengiz, Mackenzie, William, Marinho, Diane Ruschel, McFadyen, Andrew, McGill, Jim, Mitchell, John J, MPS Consensus Programme Co-Chairs, MPS Consensus Programme Steering Committee, Muenzer, Joseph, Okuyama, Torayuki, Orchard, Paul J, Scarpa, Maurizio, Stevens, Bob, Thomas, Sophie, Walker, Robert, Wynn, Robert   +30 more
core   +2 more sources

Proton conductivity of glycosaminoglycans.

PLoS ONE, 2019
Proton conductivity is important in many natural phenomena including oxidative phosphorylation in mitochondria and archaea, uncoupling membrane potentials by the antibiotic Gramicidin, and proton actuated bioluminescence in dinoflagellate.
John Selberg, Manping Jia, Marco Rolandi
doaj   +1 more source

Isoforms of corneal keratan sulfate proteoglycan.

Journal of Biological Chemistry, 1990
Bovine corneal keratan sulfate proteoglycan was found to contain three major protein components. Two proteins (37 and 25 kDa) were released from the proteoglycan by endo-beta-galactosidase, N-glycanase, or chemical deglycosylation. A smaller protein (20 kDa), not covalently linked to keratan sulfate, co-purified with the proteoglycan by conventional ...
James L. Funderburgh, Gary W. Conrad
openaire   +3 more sources

Characteristics of the Protein-Keratan Sulfate Core and of Keratan Sulfate Prepared from Bovine Nasal Cartilage Proteoglycan

Journal of Biological Chemistry, 1972
Abstract Protein-keratan sulfate core was isolated from bovine nasal cartilage proteoglycan after enzymatically removing chondroitin sulfate with chondroitinase AC from Flavobacterium heparinum. The core preparation exhibited a broad, approximately Gaussian distribution of buoyant densities in CsCl density gradients (between 1.43 and 1.58 g per ml with
Vincent C. Hascall, Rick Riolo
openaire   +3 more sources

Safety and physiological effects of two different doses of elosulfase alfa in patients with morquio a syndrome: A randomized, double-blind, pilot study. [PDF]

, 2015
The primary treatment outcomes of a phase 2, randomized, double-blind, pilot study evaluating safety, physiological, and pharmacological effects of elosulfase alfa in patients with Morquio A syndrome are herewith presented.
Berger, Kenneth I, Burton, Barbara K, Genter, Fred, Harmatz, Paul, Jones, Simon A, Lau, Heather, Lewis, Gregory D, Mitchell, John J, Muschol, Nicole, Pastores, Gregory M, Shaywitz, Adam J, Sparkes, Rebecca, Sutton, V Reid, Tarnopolsky, Mark, Treadwell, Marsha   +14 more
core   +1 more source

Sulodexide. Nephroprotective properties and horizons for use in nephrology

Медицинский совет, 2015
Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj   +1 more source

Synthesis of biotinylated keratan sulfate repeating disaccharides [PDF]

Bioscience, Biotechnology, and Biochemistry, 2014
Abstract We synthesized four types of keratan and keratan sulfate repeating disaccharides containing non-sulfate, Galβ1-4GlcNAcβ, and three types of sulfates, Gal6Sβ1-4GlcNAcβ, Galβ1-4GlcNAc6Sβ, and Gal6Sβ1-4GlcNAc6Sβ in an efficient and stereo-controlled manner. These disaccharides were conjugated with biotin via a hydrophilic linker at
Jun-ichi Tamura, Naoko Takeda
openaire   +3 more sources

Proteomics for rejection diagnosis in renal transplant patients: where are we now? [PDF]

, 2016
Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible.
Gwinner, Wilfried, Husi, Holger, Marx, David, Metzger, Jochen   +3 more
core   +1 more source