Results 51 to 60 of about 10,759 (233)
Bio-Protocol, 2017 Chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of carbohydrates, is composed of linear, sulfated repeating disaccharide sequences of N-acetyl-D-galactosamine (GalNAc) and glucuronic acid (GlcA).
Kyohei Higashi, Toshihiko Toida
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Microglial subtypes: diversity within the microglial community [PDF]
, 2019 Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current understanding revolves around microglia
Joseph, Bertrand +3 more
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Keratan Sulfate in Neuronal Network Reconstruction
Trends in Glycoscience and Glycotechnology, 2011 ケラタン硫酸は2糖の繰り返し構造を単位とするグリコサミノグリカンの一つであり、コアプロテインに共有結合することによりケラタン硫酸プロテオグリカンを生ずる。ケラタン硫酸プロテオグリカンは元来角膜抽出物において発見され、また関節軟骨中において豊富に見出されたため、これら組織における構造や生物学的機能が注目されてきた。しかし1980年代に入り中枢神経系においても見出され、神経系の発達や疾患における働きが注目を集めてきた。現在、ケラタン硫酸プロテオグリカンは生理的および損傷後神経可塑性を制御する主要な分子の一つとして受け入れられ始めている。
Kenji Kadomatsu, Kazuma Sakamoto
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Journal of Craniovertebral Junction and Spine, 2020 Morquio syndrome (MS) is an autosomal recessive defect caused by the deficiency of N-acetylgalactosamine-6-sulfatase. Odontoid hypoplasia, periodontoid soft tissue deposition, and cervical stenosis lead to myelopathy and quadriparesis in these patients ...
Suyash Singh +4 more
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BMC Musculoskeletal Disorders, 2022 Background Limited chondrocyte migration and impaired cartilage-to-cartilage healing is a barrier in cartilage regenerative therapy. Collagenase treatment and delivery of a chemotactic agent may play a positive role in chondrocyte repopulation at the ...
Yuichiro Shiromoto +9 more
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Neural Regeneration Research, 2019 Mucin-like glycoproteins have established roles in epithelial boundary protection and lubricative roles in some tissues. This mini-review illustrates alternative functional roles which rely on keratan sulphate and sialic acid modifications to mucin ...
James Melrose
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GAG-DB, the New Interface of the Three-Dimensional Landscape of Glycosaminoglycans
Biomolecules, 2020 Glycosaminoglycans (GAGs) are complex linear polysaccharides. GAG-DB is a curated database that classifies the three-dimensional features of the six mammalian GAGs (chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan ...
Serge Pérez +5 more
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Axonal pathfinding during the development of the nervous system
Annals of the Child Neurology Society, 2023 Guidance of axons sprouting from maturing neuroblasts, during intermediate trajectories and in seeking target neurons for synaptogenesis, is a fundamental developmental process in central nervous system maturation.
Harvey B. Sarnat
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Cornea organoids from human induced pluripotent stem cells. [PDF]
, 2017 The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M +5 more
core +3 more sources
A review on an imperative by-product: Glycosaminoglycans- A holistic approach
Carbohydrate Polymer Technologies and Applications, 2023 Glycosaminoglycan is a generic term for a class of minor but significant components of the body. The extraction, application, and functionalization of GAGs are essential to explore owing to their biological significance.
Bindia Sahu +4 more
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