Results 11 to 20 of about 182,642 (309)
Keratinocyte PIEZO1 modulates cutaneous mechanosensation
eLife, 2022 Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the
Alexander R Mikesell +5 more
doaj +2 more sources
Scientific Reports, 2015 A limited number of studies have investigated the potential of probiotics to promote wound healing in the digestive tract. The aim of the current investigation was to determine whether probiotic bacteria or their extracts could be beneficial in cutaneous
Walaa Mohammedsaeed +3 more
doaj +2 more sources
Advances in the pathogenesis of psoriasis: from keratinocyte perspective
Cell Death and Disease, 2022 Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells.
Xue Zhou +4 more
semanticscholar +1 more source
Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation
Cell Death and Disease, 2021 Psoriasis is a common, chronic, and recurrent inflammatory disease. It is characterized by hyperproliferation and abnormal differentiation of keratinocytes.
Yanhong Shou +3 more
semanticscholar +1 more source
Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure
Redox Biology, 2021 The ultraviolet B radiation (UVB) causes skin inflammation, which contributes to the causality and the exacerbation of a number of cutaneous diseases. However, the mechanism of UVB-driven inflammation in the skin remains poorly understood.
K. Vats +8 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 The epidermis, outermost layer of the skin, forms a barrier and is involved in innate and adaptive immunity in an organism. Keratinocytes participate in all these three protective processes.
Teruki Dainichi +20 more
doaj +1 more source
Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Cells, 2020 Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and ...
S. Liarte +2 more
semanticscholar +1 more source
Autophagy, 2020 Macroautophagy/autophagy is a cellular catabolic process that is implicated in several physiological and pathological processes. However, the role of epidermal autophagy in wound healing remains unknown.
L. Qiang +3 more
semanticscholar +1 more source
Impact of p53 Knockout on Protein Data Set of HaCaT Cells in Confluent and Subconfluent Conditions
Data, 2022 The immortalized keratinocytes, HaCaT, are a popular model for skin research (toxicity, irritation, allergic reactions, or interaction of cells). They maintain a stable keratinocyte phenotype and respond to keratinocyte differentiation stimuli.
Alexander L. Rusanov +7 more
doaj +1 more source
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
eLife, 2020 Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-epithelialization and wound healing; however, the underlying molecular ...
Jesse R. Holt +8 more
semanticscholar +1 more source