Results 1 to 10 of about 220,216 (290)

Emerging roles of keratinocytes in nociceptive transduction and regulation

open access: yesFrontiers in Molecular Neuroscience, 2022
Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence has elucidated the roles of keratinocytes in a wide range of pathophysiological processes including cutaneous nociception, pruritus, and inflammation ...
Xiaohan Xu   +7 more
doaj   +1 more source

Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions

open access: yesCells, 2021
Whilst the importance of keratinocytes as a first-line defense has been widely investigated, little is known about their interactions with non-resident immune cells.
Peter Seiringer   +9 more
doaj   +1 more source

Unraveling Transcriptome Profile, Epigenetic Dynamics, and Morphological Changes in Psoriasis-like Keratinocytes: “Insights into Similarity with Psoriatic Lesional Epidermis”

open access: yesCells, 2023
Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response to psoriasis-like inflammation.
Ameneh Ghaffarinia   +11 more
doaj   +1 more source

Keratinocyte Carcinoma [PDF]

open access: yesCA: A Cancer Journal for Clinicians, 2003
Keratinocyte carcinoma is by far the most common cancer in the United States. Basal cell carcinomas and squamous cell carcinomas account for approximately 80% and 20% of cases of KC, respectively. The term nonmelanoma skin cancer is commonly used to refer to squamous cell carcinomas and basal cell carcinomas; however, other types of nonmelanoma skin ...
Michael R, Albert, Martin A, Weinstock
openaire   +2 more sources

Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

open access: yesCells, 2020
Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.
Ophélie Pierre   +8 more
doaj   +1 more source

In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like

open access: yesCells, 2020
Skin-derived precursor cells (SKPs) are neural crest stem cells that persist in certain adult tissues, particularly in the skin. They can generate a large type of cell in vitro, including neurons.
Adeline Bataille   +12 more
doaj   +1 more source

Revisiting oxytocin generation in keratinocytes

open access: yesBiophysics and Physicobiology, 2023
Some evidence suggests that oxytocin, which is a neuropeptide conventionally thought to be synthesized in the hypothalamus and released by the posterior pituitary, is generated in peripheral keratinocytes, but the details are lacking and the mRNA ...
Kanta Fujimoto   +3 more
doaj   +1 more source

Immunohistochemical and histochemical analysis of the rat skin after local electron irradiation

open access: yesOpen Veterinary Journal, 2023
Background: Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium is highly sensitive to ionising
Grigory Demyashkin   +9 more
doaj   +1 more source

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

open access: yesProtein & Cell, 2017
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema.
Olivier Gouin   +10 more
doaj   +1 more source

In vitro Effect of Geranylgeraniol (GGOH) on Bisphosphonate-Induced Cytotoxicity of Oral Mucosa Cells

open access: yesFrontiers in Oral Health, 2022
Medication-related osteonecrosis of the jaw (MRONJ) is an often-severe complication found in patients receiving bisphosphonates in the management of Paget's, osteoporosis and metastatic bone cancer.
Krit Rattanawonsakul   +5 more
doaj   +1 more source

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