Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source
The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis
Frontiers in Immunology, 2018 Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic, environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of psoriasis have been elucidated, and, in the current model, the cross talk between ...
C. Albanesi +3 more
semanticscholar +1 more source
DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
Frontiers in Oncology, 2022 The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription domain and consequently has tumor suppressor activities whereas ΔNp63 lacks this domain and acts as an oncogene.
Zuzana Pokorna +5 more
doaj +1 more source
The Potentials and Pitfalls of a Human Cervical Organoid Model Including Langerhans Cells
Viruses, 2020 Three-dimensional cell culturing to capture a life-like experimental environment has become a versatile tool for basic and clinical research. Mucosal and skin tissues can be grown as “organoids” in a petri dish and serve a wide variety of research ...
Robert Jackson +2 more
doaj +1 more source
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
Nature Communications, 2017 Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).
Jessica F Almine +11 more
semanticscholar +1 more source
Nanomaterials, 2020 The development of products for topical applications requires analyses of their skin effects before they are destined for the market. At present, the ban on animal use in several tests makes the search for in vitro models (such as artificial skin ...
Denisse Esther Mallaupoma Camarena +3 more
doaj +1 more source
IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus
Science Translational Medicine, 2019 IFN-γ enhances keratinocyte death in lichen planus. Identifying keratinocyte killers Lichen planus is an inflammatory disease characterized by lesions on the skin or mouth.
Shuai Shao +20 more
semanticscholar +1 more source
Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]
, 2002 By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Amargo, Evangeline V. +11 more
core +5 more sources
Mediators of Inflammation, 2017 Cultured primary human keratinocytes are frequently employed for studies of immunological and inflammatory responses; however, interpretation of experimental data may be complicated by donor to donor variability, the relatively short culture lifetime ...
I. Colombo +13 more
semanticscholar +1 more source
EpCAM Induction Functionally Links to the Wnt-Enhanced Cell Proliferation in Human Keratinocytes
Cell Transplantation, 2014 Accelerating proliferation of primary keratinocytes benefits skin autografts for severely burned patients. Wnt signal, a conserved pathway controlling cell cycle and morphogenesis in embryo, also involves in cell proliferation and tumorigenesis in adult ...
Ching-I Shen +7 more
doaj +1 more source