Results 41 to 50 of about 23,162 (298)
Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons
Frontiers in Cellular Neuroscience, 2020 Neurons require a well-coordinated intercellular transport system to maintain their normal cellular function and morphology. The kinesin family of proteins (KIFs) fills this role by regulating the transport of a diverse array of cargos in post-mitotic ...
Nadine F. Joseph +5 more
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Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species
Cells, 2023 The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
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, 2016 Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Brust-Mascher, Ingrid +2 more
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Kinesin-5 inhibitor resistance is driven by kinesin-12 [PDF]
Journal of Cell Biology, 2016 The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is ...
Sturgill, Emma G. +3 more
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Mechanisms of Polarized Organelle Distribution in Neurons
Frontiers in Cellular Neuroscience, 2016 Neurons are highly polarized cells exhibiting axonal and somatodendritic domains with distinct complements of cytoplasmic organelles. Although some organelles are widely distributed throughout the neuronal cytoplasm, others are segregated to either the ...
Dylan J. Britt +3 more
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Spatial Organization of the Cytoskeleton enhances Cargo Delivery to Specific Target Areas on the Plasma Membrane of Spherical Cells [PDF]
, 2016 Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along cytoskeletal ...
Hafner, Anne E., Rieger, Heiko
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The Journal of Cell Biology, 2007 When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin ...
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Kinesin-14: the roots of reversal
BMC Biology, 2010 Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross Robert A
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Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes
, 2004 Kinesins are processive motor proteins that move along microtubules in a stepwise manner, and their motion is powered by the hydrolysis of ATP. Recent experiments have investigated the coupling between the individual steps of single kinesin molecules and
A. B. Kolomeisky +11 more
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Dynein catch bond as a mediator of codependent bidirectional cellular transport
, 2019 Intracellular bidirectional transport of cargo on microtubule filaments is achieved by the collective action of oppositely directed dynein and kinesin motors.
Chandel, Sameep +7 more
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