Results 41 to 50 of about 29,043 (290)
A standardized kinesin nomenclature [PDF]
The Journal of Cell Biology, 2004 In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin nomenclature based on 14 family designations. The scheme unifies all previous phylogenies and nomenclature proposals, while allowing individual sequence ...
Lawrence, Carolyn J +21 more
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Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons
Frontiers in Cellular Neuroscience, 2020 Neurons require a well-coordinated intercellular transport system to maintain their normal cellular function and morphology. The kinesin family of proteins (KIFs) fills this role by regulating the transport of a diverse array of cargos in post-mitotic ...
Nadine F. Joseph +5 more
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Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]
Current Biology, 2014 The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
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Molecules, 2022 Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (
Alessia Ricci +6 more
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Heterogeneity in kinesin function [PDF]
Traffic, 2017 The kinesin family proteins are often studied as prototypical molecular motors; a deeper understanding of them can illuminate regulation of intracellular transport. It is typically assumed that they function identically. Here we find that this assumption of homogeneous function appears incorrect: variation among motors’ velocities in vivo and in vitro ...
Steven P. Gross +11 more
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Microtubule-regulating kinesins [PDF]
Current Biology, 2013 Kinesins can regulate microtubule dynamics? The conventional function of kinesins, much like a molecular freight train, is to transport cargo by motoring along a microtubule (MT) track. But there exists another class of kinesins whose job relates more to track maintenance than transportation.
Ryoma Ohi, Emma G. Sturgill
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Mechanisms of Polarized Organelle Distribution in Neurons
Frontiers in Cellular Neuroscience, 2016 Neurons are highly polarized cells exhibiting axonal and somatodendritic domains with distinct complements of cytoplasmic organelles. Although some organelles are widely distributed throughout the neuronal cytoplasm, others are segregated to either the ...
Dylan J. Britt +3 more
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Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species
Cells, 2023 The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
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Ciliary kinesins beyond IFT: Cilium length, disassembly, cargo transport and signalling
Biology of the Cell, 2019 Cilia and flagella are microtubule‐based antenna which are highly conserved among eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key functions during development and tissue homoeostasis.
M. Reilly, Alexandre Benmerah
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FEBS Open Bio, 2021 Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela +5 more
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