Results 1 to 10 of about 4,438 (194)

The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]

PLoS Computational Biology, 2015
Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille, Khanh Dao Duc, David Holcman, Nathalie Rouach   +3 more
doaj   +5 more sources

Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure. [PDF]

PLoS Computational Biology, 2018
Experimental recordings in hippocampal slices indicate that astrocytic dysfunction may cause neuronal hyper-excitation or seizures. Considering that astrocytes play important roles in mediating local uptake and spatial buffering of K+ in the ...
Mengmeng Du, Jiajia Li, Liang Chen, Yuguo Yu, Ying Wu   +4 more
doaj   +5 more sources

Polyamine permeation and rectification of kir4.1 channels [PDF]

Channels, 2007
Inward rectifier K(+) (Kir) channels are expressed in multiple neuronal and glial cells. Recent studies have equated certain properties of exogenously expressed Kir4.1 channels with those of native K(+) currents in brain cells, as well as demonstrating the expression of Kir4.1 subunits in these tissues. There are nagging problems however with assigning
Eaton, Misty J, Kucheryavykh, Yuri V, Kurata, Harley T, Nichols, Colin G, Pearson, Wade L, Skatchkov, Serguei N   +5 more
core   +5 more sources

Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells. [PDF]

Biomed Res Int, 2023
The Kir4.1 channel, an inwardly rectifying potassium ion (K+) channel, is located in the hair cells of the organ of Corti as well as the intermediate cells of the stria vascularis. The Kir4.1 channel has a crucial role in the generation of endolymphatic potential and maintenance of the resting membrane potential.
Choi JS, Ahn YJ, Lee S, Park DJ, Park J, Ha SM, Seo YJ.   +6 more
europepmc   +5 more sources

Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism? [PDF]

Frontiers in Neuroscience, 2020
In the last decades, increasing evidence has revealed that a large number of channel protein and ion pumps exhibit impaired expression in cancers. This dysregulation is responsible for high proliferative rates as well as migration and invasiveness ...
Federico Brandalise, Daniela Ratto, Roberta Leone, Federico Olivero, Elisa Roda, Elisa Roda, Carlo Alessandro Locatelli, Maria Grazia Bottone, Paola Rossi   +8 more
doaj   +2 more sources

Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. [PDF]

Invest Ophthalmol Vis Sci, 2020
Diabetic retinopathy (DR) is a leading cause of visual impairment. Müller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1. Metformin, a commonly used oral antidiabetic drug, is known to elicit its action through 5' adenosine monophosphate-activated protein kinase (AMPK), a cellular metabolic ...
Alex A, Luo Q, Mathew D, Di R, Bhatwadekar AD.   +4 more
europepmc   +3 more sources

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis [PDF]

Advanced Science
Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti‐Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential.
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
doaj   +2 more sources

Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe [PDF]

Communications Biology
Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+.
Colin M. Cleary, Jack L. Browning, Moritz Armbruster, Cleyton R. Sobrinho, Monica L. Strain, Sarvin Jahanbani, Jaseph Soto-Perez, Virginia E. Hawkins, Chris G. Dulla, Michelle L. Olsen, Daniel K. Mulkey   +10 more
doaj   +2 more sources

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β [PDF]

Journal of Neuroinflammation, 2012
Objective Decreased expression of inwardly rectifying potassium (Kir) channels in astrocytes and glioma cells may contribute to impaired K+ buffering and increased propensity for seizures. Here, we evaluated the potential effect of inflammatory molecules,
Zurolo Emanuele, de Groot Marjolein, Iyer Anand, Anink Jasper, van Vliet Erwin A, Heimans Jan J, Reijneveld Jaap C, Gorter Jan A, Aronica Eleonora   +8 more
doaj   +7 more sources

Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. [PDF]

Sci Rep, 2016
Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity.
Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M.   +17 more
europepmc   +3 more sources