Results 11 to 20 of about 2,276,672 (229)

Acteoside relieves diabetic retinopathy through the inhibition of Müller cell reactive hyperplasia by regulating TXNIP and mediating Kir4.1 channels in a PI3K/Akt-dependent manner. [PDF]

PLoS ONE
Diabetic retinopathy (DR) is a severe microangiopathy of diabetes. Müller cells play an important role in the development of DR. Acteoside (ACT) has been reported to be effective in the treatment of DR.
Xiaoting Xi, Xiaolei Liu, Qianbo Chen, Jia Ma, Xuewei Wang, Yufei Gui, Yuxin Zhang, Yan Li   +7 more
doaj   +3 more sources

Hyperglycemia reduces functional expression of astrocytic Kir4.1 channels and glial glutamate uptake. [PDF]

Neuroscience, 2015
Diabetics are at risk for a number of serious health complications including an increased incidence of epilepsy and poorer recovery after ischemic stroke. Astrocytes play a critical role in protecting neurons by maintaining extracellular homeostasis and preventing neurotoxicity through glutamate uptake and potassium buffering. These functions are aided
Rivera-Aponte DE, Méndez-González MP, Rivera-Pagán AF, Kucheryavykh YV, Kucheryavykh LY, Skatchkov SN, Eaton MJ.   +6 more
europepmc   +5 more sources

Role of Kir4.1 channels in growth control of glia [PDF]

Glia, 2007
AbstractThe inwardly rectifying potassium channel Kir4.1 is widely expressed by astrocytes throughout the brain. Kir4.1 channels are absent in immature, proliferating glial cells. The progressive expression of Kir4.1 correlates with astrocyte differentiation and is characterized by the establishment of a negative membrane potential (> −70 mV) and an
Haruki, Higashimori, Harald, Sontheimer
openaire   +3 more sources

Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic strokeResearch in context

EBioMedicine, 2023
Summary: Background: Stroke is one of the most common neurological diseases in the world and is clinically manifested by transient or permanent brain dysfunction.
Xiaoqi Hong, Yujin Jian, Shenghao Ding, Jianpo Zhou, Xiaoli Zheng, Huimin Zhang, Butian Zhou, Canbin Zhuang, Jieqing Wan, Xiaoping Tong   +9 more
doaj   +3 more sources

The central role of aquaporins in the pathophysiology of ischemic stroke [PDF]

Frontiers in Cellular Neuroscience, 2015
Stroke is a complex and devastating neurological condition with limited treatment options. Brain edema is a serious complication of ischemic stroke and early edema formation can significantly contribute to infarct formation and thus represents a ...
Jasmine eVella, Christian eZammit, Giuseppe eDi Giovanni, Richard eMuscat, Mario eValentino   +4 more
doaj   +8 more sources

Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain [PDF]

Cell Reports
Summary: Intense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest ...
Olga Tyurikova, Olga Kopach, Kaiyu Zheng, Daman Rathore, Neela Codadu, Sheng-Yi Wu, Yi Shen, Robert E. Campbell, Rob C. Wykes, Kirill Volynski, Leonid P. Savtchenko, Dmitri A. Rusakov   +11 more
doaj   +2 more sources

Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases. [PDF]

Int J Mol Sci, 2021
Inwardly rectifying Kir4.1 channels in astrocytes mediate spatial potassium (K+) buffering, a clearance mechanism for excessive extracellular K+, in tripartite synapses.
Ohno Y, Kunisawa N, Shimizu S.
europepmc   +2 more sources

Role of Glyoxalase in Astrocytes’ Supportive Function Under Hyperglycemic Conditions: Aminoguanidine and Kir4.1 Channel Recovery [PDF]

Brain Sciences
Background/Objectives: Diabetes mellitus is a metabolic disorder, and hyperglycemia results in abnormal brain function. Since glycolysis is the main energy pathway in glial cells, astrocytes possess a more developed glyoxalase (Glo) system than neurons ...
Jadier Colón-Vázquez, Nathaly M. Rosado-Rivera, Joshua J. Navedo-Jackson, Arelys A. Angueira-Laureano, Yanitza Hernandez-Santiago, Geronimo Maldonado-Martinez, Miguel P. Méndez-González, Misty J. Eaton, Serguei N. Skatchkov, David E. Rivera-Aponte   +9 more
doaj   +2 more sources

Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury

Brain
SummarySpasticity, a prevalent motor issue characterized by network hyperexcitability, causes pain and discomfort, with existing treatments offering limited relief. While past research has focused on neuronal factors, the role of astrocytes in spasticity has been overlooked.
Barbay, Tony, Pecchi, Emilie, Ramirez-Franco, Jorge, Ivanov, Anton, Brocard, Frédéric, Rouach, Nathalie, Bos, Rémi   +6 more
semanticscholar   +5 more sources

Opposite effects of pH on open‐state probability and single channel conductance of Kir4.1 channels

The Journal of Physiology, 1999
1. A decrease in intracellular pH (pHi) inhibits whole-cell Kir4.1 currents. To understand channel biophysical properties underlying this inhibition, single channel Kir4.1 currents were studied in inside-out patches using symmetric concentrations of K+ applied to each side of the plasma membrane.
Z, Yang, C, Jiang
openaire   +4 more sources