In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics. [PDF]
Br J Pharmacol, 2020 Aminoglycoside antibiotics are positively charged molecules that are known to inhibit several ion channels. In this study, we have shown that aminoglycosides also inhibit the activity of Kir4.1 channels.
Morán-Zendejas R +6 more
europepmc +2 more sources
The critical role of ion channels in kidney disease: perspective from AKI and CKD [PDF]
Renal FailureIon channels, particularly those in the transient receptor potential (TRP) family, play key roles in cellular stress responses like inflammation and apoptosis, significantly impacting renal disease progression.
Chen sui zi Li +4 more
doaj +2 more sources
Kir4.1 channels in NG2-glia play a role in development, potassium signaling, and ischemia-related myelin loss. [PDF]
Commun Biol, 2018 The contribution of the inwardly rectifying K+ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in the maintenance of resting membrane potential, extracellular K+ uptake, and facilitation of glutamate uptake ...
Song F +10 more
europepmc +2 more sources
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. [PDF]
Int J Mol Sci, 2019 The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy.
Kinboshi M +7 more
europepmc +2 more sources
Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease. [PDF]
GliaAPOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Abhyankar SD +8 more
europepmc +2 more sources
Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009 This work demonstrates that extracellular Na(+) modulates the cloned inwardly rectifying K(+) channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external Na(+). We expressed Kir4.1 and Kir4.1-Kir5.1 in Xenopus oocytes to disclose if Kir4.1 and/or Kir4.
Søe, Rikke +2 more
+10 more sources
Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. [PDF]
PLoS ONE, 2018 Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels.
Kayla Thompson +5 more
doaj +1 more source
Glia, 2023 Neuronal rhythmogenesis in the spinal cord is correlated with variations in extracellular K+ levels ([K+]e). Astrocytes play important role in [K+]e homeostasis and compute neuronal information.
Tony Barbay +5 more
semanticscholar +1 more source
Inhibition of Kir4.1 potassium channels by quinacrine [PDF]
Brain Research, 2017 Inwardly rectifying potassium (Kir) channels are expressed in many cell types and contribute to a wide range of physiological processes. Particularly, Kir4.1 channels are involved in the astroglial spatial potassium buffering. In this work, we examined the effects of the cationic amphiphilic drug quinacrine on Kir4.1 channels heterologously expressed ...
Leticia G, Marmolejo-Murillo +7 more
openaire +2 more sources
Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis
Frontiers in Neurology, 2020 Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability.
Masato Kinboshi +3 more
doaj +1 more source