Results 31 to 40 of about 2,276,672 (229)

Oligodendrocyte K_ir4.1 Channels Clear Out Congested K^. [PDF]

Epilepsy Curr, 2019
Oligodendrocytes Control Potassium Accumulation in White Matter and Seizure Susceptibility. Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Elife. 2018 Mar 29;7. pii: e34829. doi: 10.7554/eLife.34829.
Lyman KA, Chetkovich DM.
europepmc   +2 more sources

Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina. [PDF]

PLoS ONE, 2011
Glial cells such as retinal Müller glial cells are involved in potassium ion and water homeostasis of the neural tissue. In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of ...
Petra G Hirrlinger, Thomas Pannicke, Ulrike Winkler, Thomas Claudepierre, Shweta Varshney, Christine Schulze, Andreas Reichenbach, William J Brunken, Johannes Hirrlinger   +8 more
doaj   +1 more source

Ketamine Reduces the Surface Density of the Astroglial Kir4.1 Channel and Inhibits Voltage-Activated Currents in a Manner Similar to the Action of Ba²⁺ on K⁺ Currents

Cells, 2023
A single sub-anesthetic dose of ketamine evokes rapid and long-lasting beneficial effects in patients with a major depressive disorder. However, the mechanisms underlying this effect are unknown.
Mićo Božić, Samo Pirnat, Katja Fink, Maja Potokar, Marko Kreft, Robert Zorec, Matjaž Stenovec   +6 more
doaj   +1 more source

Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases

Frontiers in Physiology, 2023
The inward-rectifying potassium channel subunit Kir5.1, encoded by Kcnj16, can form functional heteromeric channels (Kir4.1/5.1 and Kir4.2/5.1) with Kir4.1 (encoded by Kcnj10) or Kir4.2 (encoded by Kcnj15).
Chaojie Zhang, Chaojie Zhang, Chaojie Zhang, Chaojie Zhang, Jia Guo, Jia Guo, Jia Guo, Jia Guo   +7 more
doaj   +1 more source

Kir4.1 K⁺channels are regulated by external cations [PDF]

Channels, 2011
The inwardly rectifying potassium channel (Kir), Kir4.1 mediates spatial K(+)-buffering in the CNS. In this process the channel is potentially exposed to a large range of extracellular K(+) concentrations ([K(+)]o). We found that Kir4.1 is regulated by K(+)o.
Johan M, Edvinsson, Anish J, Shah, Lawrence G, Palmer   +2 more
openaire   +2 more sources

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

The Journal of Clinical Investigation, 2023
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Hannah Kapell, Luca Fazio, Julia Dyckow, Sophia Schwarz, Andrés Cruz-Herranz, Christina Mayer, Joaquin Campos, Elisa D’Este, Wiebke Möbius, Christian Cordano, Anne-Katrin Pröbstel, Marjan Gharagozloo, Amel Zulji, Venu Narayanan Naik, Anna Delank, Manuela Cerina, Thomas Müntefering, Celia Lerma-Martin, Jana K. Sonner, Jung Hyung Sin, Paul Disse, Nicole Rychlik, Khalida Sabeur, Manideep Chavali, Rajneesh Srivastava, Matthias Heidenreich, Kathryn C. Fitzgerald, Guiscard Seebohm, Christine Stadelmann, Bernhard Hemmer, Michael Platten, Thomas J. Jentsch, Maren Engelhardt, Thomas Budde, Klaus-Armin Nave, Peter A. Calabresi, Manuel A. Friese, Ari J. Green, Claudio Acuna, David H. Rowitch, Sven G. Meuth, Lucas Schirmer   +41 more
doaj   +1 more source

Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

Frontiers in Molecular Neuroscience, 2017
Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Although dysfunction of astrocytic Kir4.1 channels is implicated in the development of epileptic seizures, the ...
Masato Kinboshi, Masato Kinboshi, Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno   +16 more
doaj   +1 more source

Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis

Physiological Reports, 2021
The nitric oxide (NO)‐generating enzyme, NO synthase‐1β (NOS1β), is essential for sodium (Na+) homeostasis and blood pressure control. We previously showed that collecting duct principal cell NOS1β is critical for inhibition of the epithelial sodium ...
Kelly A. Hyndman, Elena Isaeva, Oleg Palygin, Luciano D. Mendoza, Aylin R. Rodan, Alexander Staruschenko, Jennifer S. Pollock   +6 more
doaj   +1 more source

Perisynaptic astrocytes as a potential target for novel antidepressant drugs

Journal of Pharmacological Sciences, 2021
Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants ...
Marcos E. Frizzo, Yukihiro Ohno
doaj   +1 more source

Disentangling astroglial physiology with a realistic cell model in silico [PDF]

, 2018
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry.
A Araque, A Chvatal, A Grosche, A Panatier, A Verkhratsky, A Volterra, A Wallraff, AM Reeves, B Djukic, BA MacVicar, BS Khakh, C Giaume, C Henneberger, CC Fink, DA Rusakov, DA Rusakov, DA Rusakov, DE Bergles, E Scemes, E Shigetomi, EA Bushong, EA Newman, F Ding, F Oschmann, G Seifert, G Ullah, G Wallach, GG Viola, I Patrushev, J Golowasch, J Grosche, J Schaff, J Sibille, K Hama, K Ogata, K Thurley, K Zheng, K Zheng, KC Chen, KP Lehre, KP Lehre, KY Zheng, LP Savtchenko, LP Savtchenko, M Nedergaard, M Pitta De, M Pitta De, MA Castro Di, MD Haustein, MJ Berridge, ML Hines, ML Hines, MR Witcher, N Bazargani, N Hernjak, N Medvedev, P Kofuji, PX Cao, R Srinivasan, R Ventura, RL Rungta, S Anders, S Sylantyev, T Hofer, T Manninen, TaufiqUrRahman, TW Chen, V Parpura, WN Ross, Z Wang, Z Zhang   +70 more
core   +3 more sources