Results 41 to 50 of about 2,276,672 (229)

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis [PDF]

New England Journal of Medicine, 2012
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known.We screened serum IgG from persons with multiple sclerosis to identify antibodies that are capable of binding to brain tissue and ...
Rajneesh, Srivastava, Muhammad, Aslam, Sudhakar Reddy, Kalluri, Lucas, Schirmer, Dorothea, Buck, Björn, Tackenberg, Veit, Rothhammer, Andrew, Chan, Ralf, Gold, Achim, Berthele, Jeffrey L, Bennett, Thomas, Korn, Bernhard, Hemmer   +12 more
openaire   +2 more sources

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source

Variable loss of Kir4.1 channel function in SeSAME syndrome mutations [PDF]

Biochemical and Biophysical Research Communications, 2010
SeSAME syndrome is a complex disease characterized by seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance. Mutations in the inwardly rectifying potassium channel Kir4.1 (KCNJ10 gene) have been linked to this condition. Kir4.1 channels are weakly rectifying channels expressed in glia, kidney, cochlea and possibly other
Xiaofang, Tang, Darwin, Hang, Andrea, Sand, Paulo, Kofuji   +3 more
openaire   +2 more sources

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

eLife, 2018
The inwardly rectifying K+ channel Kir4.1 is broadly expressed by CNS glia and deficits in Kir4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte Kir4.1 channels in controlling myelination and K+ clearance in white matter ...
Valerie A Larson, Yevgeniya Mironova, Kimberly G Vanderpool, Ari Waisman, John E Rash, Amit Agarwal, Dwight E Bergles   +6 more
doaj   +1 more source

Functional interaction between aquaporins and Kir4.1/Kir4.1‐Kir5.1 channels

The FASEB Journal, 2007
In the CNS glial cells, Kir4.1 and Kir4.1‐Kir5.1 channels are involved in clearance of K + during neuronal activity. A number of studies have shown that Kir channels are co‐localized with aquaporins (AQP4) in the glial cells, and coupled water and K ...
Rikke Søe, Dan Arne Klærke
openaire   +1 more source

Review: Dystroglycan in the Nervous System [PDF]

, 2007
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core   +2 more sources

Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model

Frontiers in Cellular Neuroscience, 2013
The inwardly-rectifying potassium (Kir) channel Kir4.1 in brain astrocytes mediates spatial K+ buffering and regulates neural activities. Recent studies have shown that loss-of-function mutations in the human gene KCNJ10 encoding Kir4.1 cause epileptic ...
Yuki eNagao, Yuya eHarada, Takahiro eMukai, Saki eShimizu, Aoi eOkuda, Megumi eFujimoto, Asuka eOno, Yoshihisa eSakagami, Yukihiro eOhno   +8 more
doaj   +1 more source

Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice

Brain Sciences, 2020
Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% of diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured
Miguel P. Méndez-González, David E. Rivera-Aponte, Jan Benedikt, Geronimo Maldonado-Martínez, Flavia Tejeda-Bayron, Serguei N. Skatchkov, Misty J. Eaton   +6 more
doaj   +1 more source

The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet

Frontiers in Physiology, 2022
Basolateral potassium channels in the distal convoluted tubule (DCT) are composed of inwardly-rectifying potassium channel 4.1 (Kir4.1) and Kir5.1. Kir4.1 interacts with Kir5.1 to form a 40 pS K+ channel which is the only type K+ channel expressed in the
Xin-Xin Meng, Hao Zhang, Gui-Lin Meng, Shao-Peng Jiang, Xin-Peng Duan, Wen-Hui Wang, Ming-Xiao Wang   +6 more
doaj   +1 more source

Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. [PDF]

, 2013
Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Binder, Devin K, Jin, Byung-Ju, Verkman, AS, Zhang, Hua   +3 more
core   +2 more sources