Results 121 to 130 of about 5,030 (211)
, 2015 International audienceATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential to the metabolic state of cells.
Moreau, Christophe J +4 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2007 目的初步探讨中国汉族人群Kir6.2基因E23K多态性与冠心病（CHD）的关系。方法提取119例CHD患者和101例对照者的基因组DNA,采用PCR-限制性位点多态性（PCR-RSP）方法检测Kir6.2基因E23K多态性分布特点,同时检测各项血脂水平。结果湖北地区汉族人群中普遍存在该位点的基因多态性,在冠心病组中,G等位基因频率高于正常组（63.4%vs.56.9%,P>0.05）;A等位基因频率低于正常组（36.6%vs.43.1%,P>0.05）,两组间等位基因频率无显著性差异（P>0.05 ...
鲁敏翔
doaj
Calcium imaging and modeling in islets with varying Cx36 and Kir6.2[ΔN30,K185Q] expression.
, 2016 A). Image of autofluorescence in GFP channel in islet lacking Kir6.2[ΔN30,K185Q] expression (left); with representative time courses of Rhod2 fluorescence in islets isolated from Cx36+/+ and Cx36-/- mice at 20mM glucose (middle); and time courses from ...
Thomas H. Hraha (625798) +4 more
core +1 more source
Neonatal diabetes - The role of KCNJ11 (Kir6.2)
, 2016 ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic β-cells KATP channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of ...
openaire +1 more source
, 2015 Les canaux potassiques sensibles à l'ATP (K-ATP) jouent un rôle fondamental au sein de la cellule, puisqu'ils ajustent le potentiel de membrane en fonction de l'état métabolique. Ils combinent deux types de protéines: le récepteur des Sulfonylurée (SUR),
Principalli, Maria Antonietta
core
, 2010 Trafficking of pancreatic K(ATP) channels to the plasma membrane critically depends on masking the endoplasmic reticulum (ER) retention signals of the SUR1 and Kir6.2 subunits upon their proper assembly into functional hetero-octamers.
Marhfour, Ihsane +6 more
core
Cantu syndrome-associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels. [PDF]
J Biol ChemGao J, Thompson ET, Nichols CG.
europepmc +1 more source
MitoQ Triggers Mitochondrial Collapse and Apoptotic Death in Glioblastoma Associated with KATP Channel Expression Changes. [PDF]
Neurochem ResKaraaslan A, Hacioglu C.
europepmc +1 more source
A New Potassium Channel on the Endoplasmic Reticulum Membrane in a Rat Brain: Electropharmacology and Molecular Evidence. [PDF]
Basic Clin NeurosciNazari M +4 more
europepmc +1 more source