Results 111 to 120 of about 402 (139)
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Targeting KNDy neurons to control GnRH pulses
Current Opinion in Pharmacology, 2022Gonadotropin-releasing hormone (GnRH) is the final output of the central nervous system that drives fertility. A characteristic of GnRH secretion is its pulsatility, which is driven by a pulse generator. Each GnRH pulse triggers a luteinizing hormone (LH) pulse.
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Obestatin May Affect the GnRH/KNDy Gene Network in Sheep Hypothalamus
Research in Veterinary Science, 2019The effects of obestatin on gonadotrophic axis activity in ruminants have not yet been determined. The aim of this study was to investigate the effect of intracerebroventricular infusions of obestatin on the gonadotrophin-releasing hormone (GnRH) mRNA and protein expressions as well as on KNDy mRNA and kisspeptin (Kiss) peptide expressions in ...
Anna Wójcik-Gładysz +2 more
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AbstractHypothalamo–pituitary–gonadal axis has been recognized as a functional unit orchestrating reproductive performance in mammals. The mechanism governing puberty onset, however, is still one of the great mysteries of biology. The present article reviews previous studies over the last century, which gradually elucidated the brain mechanism ...
Yoshihisa, Uenoyama +2 more
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GenesPrevious studies have demonstrated the essential role of the Kisspeptin/Neurokinin B/Dynorphin A (KNDy) pathway in female reproductive biology by regulating the activity of the hypothalamic–pituitary–gonadal axis.
Luis Ramos, Aidet Ruiz
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30 Central Regulation of Kndy Neurons During Undernutrition in Sheep
Journal of Animal Science, 2023Abstract Adequate energy intake is essential for reproduction. While we have known for decades that feed restriction inhibits gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) secretion, the central mechanisms that govern this reduction during undernutrition remain to be fully elucidated. The past few years, we have focused on
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Molecular and Cellular Endocrinology, 2016 Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17β-estradiol (E2) on the HPG axis.
Troy Roepke +2 more
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KNDy innervation of MCH neurons modulates sleep in an estradiol-dependent manner
Physiology, 2023Levels of circulating gonadal hormones, including estrogens, affect both subjective and objective measures of sleep quality. However, the mechanisms linking sex variables to sleep architecture are incompletely understood. One brain region known to be potently regulated by circulating levels of estradiol is the arcuate nucleus of the hypothalamus (ARH).
Bethany Beekly +3 more
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Role of KNDy neurons in the negative-feedback suppression of gonadotropin secretion in female rats
EndocrinologyAbstract The hypothalamic neurons that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy) play a crucial role in the control of gonadotropin-releasing hormone (GnRH) pulsatile release and, thereby, in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Ana C Campideli-Santana +6 more
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Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation
Nature Reviews EndocrinologyVasomotor symptoms (VMS), including hot flushes and night sweats, affect approximately 70% of people experiencing menopause and have a notable effect on quality of life. Until the past few years, the underlying neuroendocrine mechanisms remained poorly understood, limiting therapeutic options beyond menopausal hormone therapy.
Encarnación Torres +2 more
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Origins of the ‘KNDy hypothesis’ of GnRH pulse generation
Nature Reviews Endocrinology, 2022openaire +2 more sources